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Integrating research into development and ageing ('LifeSpan')

Integrating research into development and ageing ('LifeSpan')

Objective

Although human ageing has many dimensions it is a biological process that we share with nearly all living organisms. Therefore, we must comprehend the broad principles of the biology of ageing. We address this at a time when many preconceptions about the ageing process, such as that it is an ineluctable part of our biology, are being challenged. In line with the continuous increase of our lifespan, ageing may be intrinsically far more malleable than previously thought.
Ageing can only be understood by considering the entire human life history. Our life span is determined by genetic, environmental and stochastic factors, and evidence suggests that early-life events determine the individual status at the end of life. Therefore, we aim to bridge research on development with research on ageing, and to integrate these two disciplines that do not have a tradition of close interaction. We will move to and fro between experiments in (in)vertebrate models and observations in humans to test effects detected in one species as candidate longevity mechanism in the other. This approach has only been marginally explored and has never been attempted in one collaborative effort.
Some of us have begun to probe this unexplored field of research, but fragmentation in Europe must be avoided. LifeSpan ensures the future framework of ageing research that allows the appropriate questions to be asked, using the most suitable organisms, and taking the appropriate experimental and observational approach. This can only be done effectively when the research groups in Europe have the proper expertise and carry out their research in an integrative manner, in terms of science, organisation, and of a common education programme. All participants excel in science including the expertise and resources necessary for this Network. Crucially then, LifeSpan will provide the essential framework to reach European scientific excellence by """"Integrating research into Development and Ageing""""."

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Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN ACTING UNDER THE NAME LEIDEN UNIVERSITY MEDICAL CENTER

Address

Albinusdreef 2
9600 Leiden

Netherlands

Administrative Contact

Rudi G.j. WESTENDORP (Professor)

Participants (16)

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UNIVERSITY LEIDEN

Netherlands

AUSTRIAN ACADEMY OF SCIENCES

Austria

UNIVERSITY OF TARTU

Estonia

UNIVERSITY OF LAUSANNE; DEPARTMENT OF ECOLOGY AND EVOLUTION

Switzerland

UNIVERSITY OF FREIBURG

Germany

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

UNIVERSITY OF SOUTHERN DENMARK

Denmark

KAROLINSKA INSTITUTET

Sweden

NORWEGIAN UNIVERSITY OF LIFE SCIENCES

Norway

UNIVERSITY COLLEGE LONDON

United Kingdom

OSAÜHING BIODATA

Estonia

PANATECS GMBH

Germany

ERASMUS MEDICAL CENTER

Netherlands

DNAGE BV

Netherlands

EBERHARD-KARLS-UNIVERSITÄT TÜBINGEN

Germany

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE UNITÉ DE RECHERCHE 515 HOPITAL SAINT-ANTOINE

France

Project information

Grant agreement ID: 36894

  • Start date

    1 January 2007

  • End date

    31 December 2011

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 14 000 001

  • EU contribution

    € 10 000 000

Coordinated by:

ACADEMISCH ZIEKENHUIS LEIDEN ACTING UNDER THE NAME LEIDEN UNIVERSITY MEDICAL CENTER

Netherlands