Objective The present project aims at gaining new fundamental knowledge in enantioselective catalysis and co-ordination chemistry. Particular attention will be paid to the synthesis and application in homogeneous enantioselective catalysis of pioneering optically active phosphite ligands possessing stereogenic phosphorus atoms. This promising class of phosphorus ligands has been only fragmentary investigated so far, despite their P-chiral phosphine analogues represent well-established highly efficient ligands. Lack of convenient methods for the synthesis of P-chiral phosphites hinders further progress of this ligand group.Therefore, universal synthetic methods for their preparation from readily available chiral precursors is planned to be developed. Interaction of the novel P*-, P*,N- and P*,P*-ligands with common catalytic precursors (in particular Rh(I), Ir(I), Pd(II) and Pd(0) complexes) will be thoroughly investigated in order to reveal main complexation patterns and create a general model of their co-ordination behaviour. Simultaneously, the novel ligands will be applied in enantioselective hydrogenation of C=C and C=N bonds (Rh, Ir), allylic substitution and tandem allylation (Pd), hydroformylation (Rh) and conjugated addition of R2Zn and R3Al to enones (Cu).Close integration of co-ordination and catalytic experiments is expected to result in deep insight into the vitally important "ligand's structure - complexation mode - structure of the metal complex - catalytic outcome" correlations. Thanks to the pronounced versatility of chiral phosphites, high conversion and improvement of enantioselectivity up to >90% ee in the listed above catalytic processes are achievable tasks. The most efficient cationic complexes will be immobilised by ion-exchange on a sulfonated hyper-cross-linked polystyrene (unusual sponge-type polymer with unique properties) to obtain easily recyclable catalysts (>3 cycles without loss in activity and enantioselectivity).As an independent approach to reusable transition metal catalytic systems, conducting of reactions in ionic liquids followed by extraction of the products with non-polar solvents is suggested. Moreover, synthesis of previously not adequately explored optically active ionic liquids and their application as chiral promoters is planned. Potential practically valuable results include development of efficient catalytic synthesis of versatile chiral building blocks, e.g. allyl amines and substituted morpholine heterocycles.Also, our plans include convenient pathway to a key intermediate for the synthesis of Ibuprofen and pharmaceutically interesting optically active 1-arylethylphosphonates, e.g. a phosphorus analogue of Naproxen. The line of participating teams was thoroughly selected to provide deep experience and state-of-the-art equipment in all the required fields. Combined efforts of the participating world-class groups will have a synergetic effect and lift a joint research up to a principally higher level. Keywords Co-ordination & Organometallic Chemistry Homogeneous Catalysis Synthesis & Growth Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Topic(s) Data not available Call for proposal Data not available Funding Scheme Data not available Coordinator LEIBNIZ-INSTITUT FÜR ORGANISCHE KATALYSE EU contribution No data Address ALBERT EINSTEIN STRASSE, 29A ROSTOCK Germany See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUTE OF CHEMISTRY (MAS) Moldova EU contribution No data Address ACADEMIEI, 1 CHISINAU See on map Total cost No data MOSCOW STATE UNIVERSITY (MGU) Russia EU contribution No data Address VOROBIEVY GORY MOSCOW See on map Total cost No data NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS Russia EU contribution No data Address VAVILOV STREET, 28 MOSCOW See on map Total cost No data RYAZAN STATE UNIVERSITY Russia EU contribution No data Address SVOBODA STR., 46 RYAZAN See on map Total cost No data UNIVERSITY OF GENEVA Switzerland EU contribution No data Address QUAI ERNEST ANSERMET, 30 GENEVA See on map Total cost No data
