Objectif Single nucleotide polymorphisms of 56 genes (CD1A, CD1B, CD1C, CD1D, CD1E, CD80, CD86, CD28, B7H1, B7H2, B7H3, ICOS, OX40, IL12A, IL12B, IL18, IL10, IL1B, TNFA, IFNG, IL4, IL1RN, TBET, GATA3, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, CISH, PIAS1, PIAS3, PIASX, PIASY, IL12R1, IL12R2, IL10RA, IL10RB, IL18R1, IFGR1, IFGR2, IL4RA, IL2RG, IL1R1, IL1R2, TNFAR, TPGER4) responsible for cellular and humoral immune responses and inflammatory pathways will be studied in biosamples banks of atopic asthma patients, their relatives, tuberculosis patients, asthma and helminths Opisthorchis felineus patients, and healthy controls to establish relationship between genetic variation and polar immunological phenotypes. Mouse model will be used to test the effects of genetic background on IgE production after BCG vaccination. This will be analyzed by BCG vaccination of selected low and high responding CcS/Dem mouse strains and establishing their serum IgE levels. Novel genetic regions of interest for human studies will be identified in mouse model by analysis of the effect of BCG vaccination in congenic sub-strains carrying different recombinant haplotypes. The project will bring together human association study and mouse experimental study to test the hypothesis that allergic and infectious diseases may have a common genetic background in spite of their immunological polarity. Mots‑clés Human Genetics Immunology Public Health Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Thème(s) Data not available Appel à propositions Data not available Régime de financement Data not available Coordinateur IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Contribution de l’UE Aucune donnée Adresse DOVEHOUSE STREET LONDON Royaume-Uni Voir sur la carte Coût total Aucune donnée Participants (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire INSTITUTE OF MEDICAL GENETICS Russie Contribution de l’UE Aucune donnée Adresse NAB. R. USHAIKI, 10 TOMSK Voir sur la carte Coût total Aucune donnée INSTITUTE OF MOLECULAR GENETICS (ASCR) Tchéquie Contribution de l’UE Aucune donnée Adresse FLEMING. NAM., 2 PRAGUE Voir sur la carte Coût total Aucune donnée SIBERIAN STATE MEDICAL UNIVERSITY Russie Contribution de l’UE Aucune donnée Adresse MOSKOVSKY TRAKT, 2 TOMSK Voir sur la carte Coût total Aucune donnée