Cel Single nucleotide polymorphisms of 56 genes (CD1A, CD1B, CD1C, CD1D, CD1E, CD80, CD86, CD28, B7H1, B7H2, B7H3, ICOS, OX40, IL12A, IL12B, IL18, IL10, IL1B, TNFA, IFNG, IL4, IL1RN, TBET, GATA3, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, CISH, PIAS1, PIAS3, PIASX, PIASY, IL12R1, IL12R2, IL10RA, IL10RB, IL18R1, IFGR1, IFGR2, IL4RA, IL2RG, IL1R1, IL1R2, TNFAR, TPGER4) responsible for cellular and humoral immune responses and inflammatory pathways will be studied in biosamples banks of atopic asthma patients, their relatives, tuberculosis patients, asthma and helminths Opisthorchis felineus patients, and healthy controls to establish relationship between genetic variation and polar immunological phenotypes. Mouse model will be used to test the effects of genetic background on IgE production after BCG vaccination. This will be analyzed by BCG vaccination of selected low and high responding CcS/Dem mouse strains and establishing their serum IgE levels. Novel genetic regions of interest for human studies will be identified in mouse model by analysis of the effect of BCG vaccination in congenic sub-strains carrying different recombinant haplotypes. The project will bring together human association study and mouse experimental study to test the hypothesis that allergic and infectious diseases may have a common genetic background in spite of their immunological polarity. Słowa kluczowe Human Genetics Immunology Public Health Program(-y) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania Data not available Koordynator IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Wkład UE Brak danych Adres DOVEHOUSE STREET LONDON Zjednoczone Królestwo Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko INSTITUTE OF MEDICAL GENETICS Rosja Wkład UE Brak danych Adres NAB. R. USHAIKI, 10 TOMSK Zobacz na mapie Koszt całkowity Brak danych INSTITUTE OF MOLECULAR GENETICS (ASCR) Czechy Wkład UE Brak danych Adres FLEMING. NAM., 2 PRAGUE Zobacz na mapie Koszt całkowity Brak danych SIBERIAN STATE MEDICAL UNIVERSITY Rosja Wkład UE Brak danych Adres MOSKOVSKY TRAKT, 2 TOMSK Zobacz na mapie Koszt całkowity Brak danych
