CORDIS
EU research results

CORDIS

English EN

A combined microbicidal-immunizing strategy against SIV and HIV infection

Project information

Grant agreement ID: 36928

  • Start date

    1 May 2007

  • End date

    31 October 2009

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 1 268 568

  • EU contribution

    € 1 100 000

Coordinated by:

KING'S COLLEGE LONDON

United Kingdom

Objective

The objective of the proposed project is to establish proof of concept that a tri-molecular construct, consisting of MHC antigens combined with microbial HSP70 and extracellular CCR5 can be utilized in microbicidal, preventive and therapeutic immunisation. This strategy utilizes a novel microbicidal construct to protect against mucosal SHIV infection in female macaques.

However, as the construct is immunogenic, repeated applications will elicit mucosal, regional and systemic immunity. The preventive strategy is based on two 'experiments of nature', alloimmunity and homozygous '32 CCR5 mutation. The microbicidal-immunogenic agent elicits innate antiviral responses and targets different stages in the infectious process. Investigation of the three preventive modalities are outlined below.
- To select 3 common macaque MHC molecules (Mamu A1,A4,A8), expressed as novel Dextramer constructs, to inhibit mucosal transmission of SHIV.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

KING'S COLLEGE LONDON

Address

Strand
London

United Kingdom

Participants (3)

DAKO DENMARK A/S

Denmark

LIONEX DIAGNOSTICS & THERAPEUTICS GMBH

Germany

SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL

Sweden

Project information

Grant agreement ID: 36928

  • Start date

    1 May 2007

  • End date

    31 October 2009

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 1 268 568

  • EU contribution

    € 1 100 000

Coordinated by:

KING'S COLLEGE LONDON

United Kingdom