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A genome-wide mapping and functional genomics approach to elucidating precocious coronary artery disease

Objective

A programme is proposed, by an established European consortium, that will exploit advances in complex trait genetics and functional genomics to discover novel susceptibility genes for coronary artery disease (CAD). The aim is to identify novel proteins and pathways implicated in atherosclerosis and arterial thrombosis in order to define new targets for prevention and treatment and to devise diagnostic tools that identify disease mechanisms in individuals. The PROCARDIS programme has assembled a uniquely large and carefully phenotyped collection of subjects with early CAD: >2600 affected sibling pairs; >1300 two generation 'trios'; > 5000 genetically enriched cases; >5000 matched controls free from CAD. A genome-wide linkage screen has been completed, identifying and replicating a novel locus on chromosome 17; genetic association has already been demonstrated within this, and another, locus. The proposed second phase of PROCARDIS will incorporate: a definitive genome-wide association analysis, substantial new investment in bioinformatics and functional genomics platforms (as will be needed to exploit the linkage and association data), and measurement of novel intermediate phenotypes that will yield biomarkers for CAD risk and quantitative traits for genetic analysis. Additional academic and SME partners have been selected to reinforce the existing consortium, each with unique and complementary expertise, to address the needs of post-genome research. PROCARDIS will integrate a critical mass to attain ambitious and clearly defined objectives; by adopting parallel approaches, the PROCARDIS programme can include 'higher risk' components without endangering the overall outcome. The results will address a priority theme, will give impetus to Europe's competitiveness and will satisfy major societal needs'.

Call for proposal

FP6-2005-LIFESCIHEALTH-6
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Funding Scheme

IP - Integrated Project

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Address
University Offices, Wellington Square
Oxford
United Kingdom

Participants (14)

KAROLINSKA INSTITUTET
Sweden
Address
Nobelsväg 5
Stockholm
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
Address
Via Eritrea, 62
Milano
CONSORTIUM NATIONAL DE RECHERCHE EN GENOMIQUE - CNG
France
Address
2 Rue Gaston Cremieux
CP 5721 Evry
INSTITUT DE RECERCA DEL HOSPITAL DE LA SANTA CREU I SANT PAU
Spain
Address
C/ Sant Antoni M Claret, 167
Barcelona
UNIVERSITÀ DEGLI STUDI DI MILANO
Italy
Address
Via Festa Del Perdono, 7
Milano
CLINICAL GENE NETWORKS AB
Sweden
Address
Karolinska Science Park, Fogdevreten 2B
Stockholm
ASTRAZENECA
Sweden
Address
Västra Mälarhamnen
Södertälje
DIGILAB BIOVISION GMBH
Germany
Address
Feodor-lynen-strasse 5
Hannover
METABOMETRIX LIMITED
United Kingdom
Address
Rsm, Prince Consort Road
London
COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Address
Batiment Le Ponant D - 25 Rue Le Blanc
Paris
THE UNIVERSITY OF SURREY
United Kingdom
Address
Stag Hill
Guildford
UPPSALA UNIVERSITET
Sweden
Address
St Olofsgatan 10B
256 Uppsala
GESELLSCHAFT FÜR ARTERIOSKLEROSEFORSCHUNG E.V.
Germany
Address
Domagkstrasse 3
Münster
CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL
Italy
Address
Via Giuseppe Mussi 1
Milano