Objectif NEUROscreen is an industry-lead project combining novel neural stem cell bioassays & post-genomic chemical genetics to discover potential drugs of relevance to neurological diseases, regenerative medicine & cancer. Small molecule inhibitors of the growth of clonal, human neural cancer stem cells have the prospect of being unique medicines targeting the elusive cancer stem cell. Chemical modulators augmenting the growth, survival or differentiation of normal brain cells have a prospect as preventative or regenerative medicines for neurodegenerative diseases i.e. Alzheimer's, stroke & Huntington's disease. The consortium will use quality controlled cell lines & genetic engineering technology to design unique bioassays with which the biological modulating capacity of small molecules will be evaluated in a multi-replicate manner. Advanced chemistry will be used for the intuitive design and synthesize of biologically active molecules. Screening will be achieved with cells made to a quality & quantity via innovative bioprocesses & handled with state of the art robotics. The project will enhance the utility of the cell lines by delimiting the in vitro neural potency of the stem cells; ongoing determination of differentiation capacity serves as a rigorous confirmation of utility. The project will focus on specific activities germane to a wider applied research field than its seeding project EuroStemCell. The consortium & project have been designed with a crucial alignment in mind to objectives of the Work Programme/Specific Programme for Integrating & strengthening the ERA i.e. gender & innovation aspects in research, international cooperation (3 countries & a new member state) and fostering ethical awareness in research involving human stem cells. More than 50% of partners represent European small- & medium-sized companies and this balance structures a consortium with greater potential than individual parts & will directly strengthen the ERA foundations.' Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicineneurologystroke Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) LSH-2005-1.2.5-3 - Use of cell lines to define new bioassays for the identification of therapeutic bio-molecules (especially orientated towards small and medium sized companies) Appel à propositions FP6-2005-LIFESCIHEALTH-6 Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur STEM CELL SCIENCES UK LTD Contribution de l’UE Aucune donnée Adresse SALTIRE COURT, 20 CASTLE TERRACE EDINBURGH Royaume-Uni Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (8) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire DIALECTICA SRL Italie Contribution de l’UE Aucune donnée Adresse VIALE PASTEUR, 10 NERVIANO, MILAN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée BIOREP SRL Italie Contribution de l’UE Aucune donnée Adresse GALLERIA PASSARELLA N.2 MILAN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée LIFE & BRAIN GMBH Allemagne Contribution de l’UE Aucune donnée Adresse SIGMUND-FREUD-STR.25 BONN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Royaume-Uni Contribution de l’UE Aucune donnée Adresse THE OLD SCHOOLS, TRINITY LANE CAMBRIDGE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée MEDICAL RESEARCH COUNCIL - NATIONAL INSTITUTE FOR MEDICAL RESEARCH Royaume-Uni Contribution de l’UE Aucune donnée Adresse 20 PARK CRESCENT LONDON Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée SUMMIT PLC Royaume-Uni Contribution de l’UE Aucune donnée Adresse 91 MILTON PARK, ABINGDON OXFORDSHIRE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée RHEINISCHE FRIEDRICH WILHELMS UNIVERSITÄT BONN Allemagne Contribution de l’UE Aucune donnée Adresse REGINA-PACIS-WEG 3 BONN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI MILANO Italie Contribution de l’UE Aucune donnée Adresse VIA FESTA DEL PERDONO 7 MILAN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée