Objectif A miscellany of new strategies, experimental techniques and theoretical approaches are emerging in the ongoing battle against cancer. The objective of the proposal is to model the biomechanical behavior of tumor growth in order to verify the efficiency of anti-cancer therapeutic actions.The main purpose is to study the influence of the structural biology of tumor cells and its vascular network on the determination of the mechanical characteristics of cancerous mass growth. Experiments will be held in synergy with clinicians and biologists, performing both in-vivo and in-vitro (using multi-cell spheroids and mono-layer cultures) examinations, with the design and the fabrication of appropriate micro or nano sensing devices.Peculiar and innovative aspects of the modeling effort include:-different chemotactic sensitivities for proliferative and quiescent cells;-regenerative characteristics of hypoxic cells;-investigation of residual stresses and memory of the cancerous mass;-permeability and heterogeneities Champ scientifique medical and health sciencesclinical medicineoncologyskin cancermelanomanatural sciencesbiological sciencesdevelopmental biologymedical and health sciencesclinical medicineoncologycolorectal cancernatural sciencesbiological sciencesbiophysicsnatural sciencesbiological sciencesmolecular biologystructural biology Mots‑clés Mechanical properties anti-cancer therapy applied mathematics bioengineering medical physics micro- and nano-sensors residual stress statistical physics Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Appel à propositions FP6-2005-MOBILITY-5 Voir d’autres projets de cet appel Régime de financement EIF - Marie Curie actions-Intra-European Fellowships Coordinateur CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Contribution de l’UE Aucune donnée Adresse 3 rue Michel-Ange PARIS France Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée