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Estrogens and women ageing

Objective

In women estrogens and their cognate receptors regulate reproductive activities and exert protective functions in skeletal, cardiovascular and nervous systems. With the increased life expectancy women spend now more than one third of their life in menopause, a physiological state in which ovaries stop producing sexual hormones. To date risks and benefits of post-menopause hormone replacement therapy (HRT) are still unclear. Indeed, clinical results are in strong conflict with experimental results, the latter showing a clear protective effect of estrogens against bone, vessel, skin and brain malfunctions.

EWA will build on existing knowledge, reagents and infrastructures landmarks of European excellence in estrogen research to focus on:
a) generation of innovative cell and animal models for the identification of the safest compounds to be used in HRT;
b) ascertainment of the therapeutic efficacy and risks of known and novel molecules to be used for HRT;

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Coordinator

UNIVERSITÀ DEGLI STUDI DI MILANO

Address

Via Festa Del Perdono, 7
Milano

Italy

Participants (7)

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THE UNIVERSITY OF MANCHESTER

United Kingdom

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

CONSORTIUM FOR RESEARCH, PREVENTION AND TREATMENT OF METABOLIC AND ENDOCRINE DISEASES

Italy

KAROLINSKA INSTITUET

Sweden

HORMOS MEDICAL CORPORATION

Finland

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE - GROUPEMENT D'INTERET ECONOMIQUE

France

Project information

Grant agreement ID: 518245

  • Start date

    1 January 2006

  • End date

    31 December 2008

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 3 003 132

  • EU contribution

    € 2 375 000

Coordinated by:

UNIVERSITÀ DEGLI STUDI DI MILANO

Italy

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