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Investigation of metabolic processes underlying brain myelination defects using magnetic resonance spectroscopy of oligodendrocyte extracts

Objective

Genetic factors are responsible for many degenerative diseases of the nervous system. Proteolipid protein (PLP), the most abundant myelin protein of the central nervous system (CNS), is positioned in compact myelin, and alterations in the processing of PLP are a major cause in inherited diseases of CNS myelin. For instance, the Pelizaeus Merzbacher disease is a disorder of the central nervous myelination, caused in most cases by mutations involving the PLP gene.

It has been known for several years that myelin formation in the mammalian CNS is closely related to the oligodendrocyte population, and that the latter may be regulated by apoptosis. It is also known that PLP mutations resulting in demyelination lead to extended oligodendrocyte apoptosis. The proposed research aim is to investigate metabolic processes underlying myelination defects in the CNS.

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Coordinator

UNIVERSITE LOUIS PASTEUR

Address

France

Administrative Contact

Project information

Grant agreement ID: 16487

  • Start date

    Not Available

  • End date

    Not Available

Funded under:

FP6-MOBILITY

Coordinated by:

UNIVERSITE LOUIS PASTEUR

France