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Systematic functional analysis of intracellular parasitism as a model of genomes conflict

Systematic functional analysis of intracellular parasitism as a model of genomes conflict

Objective

The research program is a multidisciplinary functional genomics approach to study fundamental biological processes relevant to human health and to develop bioinformatics tools in systems biology. It will decipher the complex regulatory networks that control basic cellular processes in the context of intracellular pathogen infection as a paradigm of host/pathogen genomes conflict.

This project will model the innate immune response of macrophages from two species (humans and mice) to an intracellular pathogen: Leishmania parasite. This model is one of the most intensively investigated at the levels of parasite, host immune response and genetics, and allows testing and validating theoretical models in the light of already available and expected data. In a combined strategy of experimental and theoretical work, we will systematically capture data on different levels of cellular information using state-of-the-art multiparametric molecular technologies.

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Coordinator

BIOBASE GMBH

Address

Halchtersche Strasse 33
Wolfenbuttel

Germany

Administrative Contact

Frank SCHACHERER (Dr)

Participants (8)

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SARL SKULD-TECH

France

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

INSTITUT PASTEUR

France

FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX

Belgium

INSTITUT PASTEUR DE TUNIS

Tunisia

UNIVERSITY OF THE WESTERN CAPE

South Africa

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

France

INSTITUTE OF SYSTEMS BIOLOGY, LTD

Russia

Project information

Grant agreement ID: 37231

  • Start date

    1 September 2007

  • End date

    28 February 2011

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 2 447 133

  • EU contribution

    € 1 840 719

Coordinated by:

BIOBASE GMBH

Germany