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Contribution of molecular epidemiology and host-pathogen genomics to understand Chlamydial trachomatis disease

Contribution of molecular epidemiology and host-pathogen genomics to understand Chlamydial trachomatis disease

Objective

Chlamydia trachomatis (CT) infections are responsible for both the world leading cause of blindness (trachoma) and the most prevalent sexually transmitted disease which is strongly associated with pelvic inflammatory disease, ectopic pregnancy, and tubal infertility. Preliminary twin study-based findings of members of this consortium estimate that there is a 40% genetic predisposition to CT infections. In order to fully exploit human genomics in the battle against CT infections, it is necessary to reliably determine aforementioned genetic predisposition at the gene level to CT infection and to define a genetic fingerprint that can be used as a marker for this predisposition. The EpiGenChlamydia CA aims to structure trans-national research to such degree that comparative genomics and genetic epidemiology on large numbers of unrelated individuals can be performed.

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Coordinator

Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patientenzorg, Waarvan Uitgaat vu Medisch Centrum (Vu University Medical Centre)

Address

De Boelelaan 1105
Amsterdam

Netherlands

Administrative Contact

Servaas Antonie MORRÉ (PhD)

Participants (18)

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Academisch Medisch Centrum Bij de Universtiteit van Amsterdam

Netherlands

Beckman Research Institute of the City of Hope

United States

Erasmus Medical Center

Netherlands

Health Protection Agency

United Kingdom

Helsingin Yliopisto

Finland

London School of Hygiene & Tropical Medicine

United Kingdom

Microbiome Ltd

Netherlands

Morehouse School of Medicine

United States

Municipal Health Service

Netherlands

National Eye Care Programme

The Gambia

National Institute of Public Health and the Environment

Netherlands

National Public Health Institute

Finland

STI Aids Netherlands

Netherlands

Skejby Sygehus, Aarhus University Hospital (Aarhus Universitetshospital)

Denmark

Stiftelsen for Industriell og Teknisk Forskning Ved Norges Tekniske Høgskole

Norway

The Chancellor, Masters and Scholars of the University of Oxford

United Kingdom

Universiteit Maastricht

Netherlands

Uppsala Universitet

Sweden

Project information

Grant agreement ID: 37637

  • Start date

    1 July 2007

  • End date

    31 December 2009

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 450 000

  • EU contribution

    € 450 000

Coordinated by:

Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patientenzorg, Waarvan Uitgaat vu Medisch Centrum (Vu University Medical Centre)

Netherlands