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Transverse, Intrafascicular Multichannel Electrode system for induction of sensation and treatment of phantom limb pain in amputees

Transverse, Intrafascicular Multichannel Electrode system for induction of sensation and treatment of phantom limb pain in amputees

Objective

Amputation of a limb is a surgical intervention used as a last resort to remove irreparably damaged, diseased, or congenitally malformed limbs where retention of the limb is a threat to the well-being of the individual. The procedure traumatically alters the body image, but often leaves sensations that refer to the missing body part, the phantom limb. In 50-80% of cases, these sensations are painful and currently, there are no effective treatment modalities. Given sufficient control over a large number of nerve fibers, a neural interface may be able to artificially evoke sensations of touch, or counteract the phantom limb pain. The application of Micro/nano technologies with functional electrical micro stimulation can not only pave the road towards a treatment, but also also provide amputees a means to sense virtual environments directly. The ultimate aim of this project is to develop this novel Human Machine Interface (HMI). A novel microfabricated neural interface, the Thin-film Intrafascicular Multichannel Electrode array, and implantable multichannel stimulator system will form the key core technological developments in the project. The work is structured in 10 work packages in three phases. The technological development phase will model, design, manufacture and characterize the multi-channel electrode (TIME) and design, manufacture and test an implantable, multi-channel stimulator. In vivo characterization phase will evaluate the TIME electrodes for biocompatibility, stability and chronic safety in animals and develop a psychophysical test platform for system integration. Finally, pre-clinical evaluation will test the system in short-term implants in amputee subjects. The work will provide direct contribution to the next-generation smart systems in the ICT-2007.3.6 Nano/Micro priority, strengthen Europe's leading position in advanced electronic systems/biomedical applications, and improve the quality of life for amputees with phantom limb pain
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Coordinator

AALBORG UNIVERSITET

Address

Fredrik Bajers Vej 5
9220 Aalborg

Denmark

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 904 476

Administrative Contact

Winnie Jensen (Ms.)

Participants (9)

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ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

Germany

EU Contribution

€ 595 140

UNIVERSITAT AUTONOMA DE BARCELONA

Spain

EU Contribution

€ 429 409

UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES

France

EU Contribution

€ 376 032

OBELIA SARL

France

EU Contribution

€ 499 486

UNIVERSITA CAMPUS BIO MEDICO DI ROMA

Italy

EU Contribution

€ 363 199

SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA

Italy

EU Contribution

€ 482 258

THE TRUSTEES OF INDIANA UNIVERSITY

United States

INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE

France

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

Project information

Grant agreement ID: 224012

Status

Closed project

  • Start date

    1 May 2008

  • End date

    30 April 2013

Funded under:

FP7-ICT

  • Overall budget:

    € 4 763 777

  • EU contribution

    € 3 650 000

Coordinated by:

AALBORG UNIVERSITET

Denmark