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Image-based Multi-scale Physiological Planning for Ablation Cancer Treatment

Image-based Multi-scale Physiological Planning for Ablation Cancer Treatment

Objective

IMPPACT will develop an intervention planning and monitoring application for Radiofrequency Ablation (RFA) of malignant liver tumours. RFA is a minimally invasive form to treat cancer without open surgery, by placing a needle inside the malignancy and destroying it through intensive heating. Though the advantages of this approach are obvious, the intervention is currently hard to plan, almost impossible to monitor or assess, and therefore is not the first choice for treatment. IMPPACT will develop a physiological model of the liver and simulate the intervention's result, accounting for patient specific physiological factors. Gaps in the understanding of particular aspects of the RFA treatment will be closed by multi-scale studies on cells and animals. New findings will be evaluated microscopically and transformed into macroscopic equations. The long-established bio-heat equation will be extended to incorporate multiple scales. Validation will be performed at multiple levels. Images from ongoing patient treatment will be used to cross check validity for human physiology. Final validation will be performed at macroscopic level through visual comparison of simulation and treatment results gathered in animal studies and during patient treatment. This extensive validation together with a user-centred software design approach will guarantee suitability of the solution for clinical practice. The consortium consists of two Hospitals, three Universities, one Research Institute and one industrial SME. The final project deliverables will be the patient specific intervention planning system and an augmented reality training simulator for the RFA intervention.

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Address

Hansastrasse 27c
80686 Munchen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 598 413

Administrative Contact

Marie Fuchs (Ms.)

Participants (7)

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MEDIZINISCHE UNIVERSITAT GRAZ

Austria

EU Contribution

€ 838 928

TECHNISCHE UNIVERSITAET GRAZ

Austria

EU Contribution

€ 691 982

UNIVERSITAET LEIPZIG

Germany

EU Contribution

€ 186 446

Teknillinen korkeakoulu

Finland

EU Contribution

€ 219 215

AALTO KORKEAKOULUSAATIO SR

Finland

EU Contribution

€ 132 875

NUMA ENGINEERING SERVICES LIMITED

Ireland

EU Contribution

€ 440 806

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 354 702

Project information

Grant agreement ID: 223877

Status

Closed project

  • Start date

    1 September 2008

  • End date

    31 December 2011

Funded under:

FP7-ICT

  • Overall budget:

    € 4 551 188

  • EU contribution

    € 3 463 367

Coordinated by:

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany