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EUROPEAN DRUG INITIATIVE ON CHANNELS AND TRANSPORTERS

Objective

The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infrastructure for scientists characterising channel and transport functions in man and pathogenic microorganisms. Our experts in the analyses of all the databases of these membrane proteins and molecular modelling will work with our industrial partners on specific targets chosen for their potential to improve the health of European citizens, increase the competitiveness of European health-related industries and businesses and address global health issues. EDICT will increase knowledge of biological processes and mechanisms involved in normal health and in specific disease situations, and transpose this knowledge into clinical applications. By combining computational and experimental analyses, existing detailed molecular models of channel and transporter proteins, and novel structures derived by our partners, will be analysed to identify the critical regions constituting drug targets. These basic discoveries will be translated via in silico and experimental strategies with our industrial partners into the design of novel drugs that modify activities of the membrane proteins for the benefit of the patients. The range of human proteins covered includes potassium channels, anion and cation transporters, neurotransmitter transporters, cation-transporting ATPases and mitochondrial transporters. Structures of bacterial homologues to the human proteins are exploited to inform the studies of their human counterparts
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Coordinator

UNIVERSITY OF LEEDS

Address

Woodhouse Lane
Ls2 9jt Leeds

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 890 220,87

Administrative Contact

Kathy Brownridge (Ms.)

Participants (27)

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UNIVERSITE DE LAUSANNE

Switzerland

EU Contribution

€ 244 228

GOETEBORGS UNIVERSITET

Sweden

EU Contribution

€ 319 534

ASTON UNIVERSITY

United Kingdom

EU Contribution

€ 308 551

UNIVERSITAT BASEL

Switzerland

EU Contribution

€ 282 600

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 836 100

FORSCHUNGSVERBUND BERLIN EV

Germany

EU Contribution

€ 179 325

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Germany

EU Contribution

€ 607 128

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 346 256,40

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 289 442

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Germany

EU Contribution

€ 229 200

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

EU Contribution

€ 351 789

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 311 302,50

MEDICAL RESEARCH COUNCIL

United Kingdom

EU Contribution

€ 1 389 510,75

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 335 516,25

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 583 073

ASTRAZENECA AB

Sweden

EU Contribution

€ 209 010

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 650 480,25

STOCKHOLMS UNIVERSITET

Sweden

EU Contribution

€ 516 720

M V LOMONOSOV MOSCOW STATE UNIVERSITY

Russia

EU Contribution

€ 106 800

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

EU Contribution

€ 369 328

UNIVERSITA DEGLI STUDI DI MILANO

Italy

EU Contribution

€ 142 800

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)

Spain

EU Contribution

€ 185 904

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 302 160

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 229 900

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 264 960

XENTION CAMBRIDGE

United Kingdom

EU Contribution

€ 209 268

UNIVERSITAETSKLINIKUM FREIBURG

Germany

EU Contribution

€ 205 449,98

Project information

Grant agreement ID: 201924

Status

Closed project

  • Start date

    1 February 2008

  • End date

    30 June 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 15 718 166,68

  • EU contribution

    € 11 896 557

Coordinated by:

UNIVERSITY OF LEEDS

United Kingdom