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EUROPEAN DRUG INITIATIVE ON CHANNELS AND TRANSPORTERS

Objective

The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infrastructure for scientists characterising channel and transport functions in man and pathogenic microorganisms. Our experts in the analyses of all the databases of these membrane proteins and molecular modelling will work with our industrial partners on specific targets chosen for their potential to improve the health of European citizens, increase the competitiveness of European health-related industries and businesses and address global health issues. EDICT will increase knowledge of biological processes and mechanisms involved in normal health and in specific disease situations, and transpose this knowledge into clinical applications. By combining computational and experimental analyses, existing detailed molecular models of channel and transporter proteins, and novel structures derived by our partners, will be analysed to identify the critical regions constituting drug targets. These basic discoveries will be translated via in silico and experimental strategies with our industrial partners into the design of novel drugs that modify activities of the membrane proteins for the benefit of the patients. The range of human proteins covered includes potassium channels, anion and cation transporters, neurotransmitter transporters, cation-transporting ATPases and mitochondrial transporters. Structures of bacterial homologues to the human proteins are exploited to inform the studies of their human counterparts

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Coordinator

UNIVERSITY OF LEEDS
Address
Woodhouse Lane
LS2 9JT Leeds
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 890 220,87
Administrative Contact
Kathy Brownridge (Ms.)

Participants (27)

UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 244 228
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alexandra Degago (Ms.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 319 534
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margareta Ahlqwist (Dr.)
ASTON UNIVERSITY
United Kingdom
EU contribution
€ 308 551
Address
Aston Triangle
B4 7ET Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eric Bourguignon (Mr.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 282 600
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Urs Mueller (Dr.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 836 100
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
Administrative Contact
Joachim Bormann (Dr.)
FORSCHUNGSVERBUND BERLIN EV
Germany
EU contribution
€ 179 325
Address
Rudower Chaussee 17
12489 Berlin
Activity type
Research Organisations
Administrative Contact
Anne Hoener (Dr.)
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
EU contribution
€ 607 128
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christoph Denecke (Mr.)
University of Zurich
Switzerland
EU contribution
€ 346 256,40
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Raimund Dutzler (Ms.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 289 442
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johanna Blatter (Ms.)
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
EU contribution
€ 229 200
Address
Universitaetsstrasse 1
40225 Dusseldorf
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Uwe Droste (Mr.)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 351 789
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Poutsma (Dr.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 311 302,50
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Jacques Saudraix (Mr.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 1 389 510,75
Address
North Star Avenue Polaris House
SN2 1FL Swindon
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Irina James (Ms.)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 335 516,25
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Helle Alstrup (Ms.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 583 073
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Brooke Alasya (Ms.)
ASTRAZENECA AB
Sweden
EU contribution
€ 209 010
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kay Callaghan (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 650 480,25
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael John Wilkinson (Mr.)
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 516 720
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ann Nielsen (Ms.)
M V LOMONOSOV MOSCOW STATE UNIVERSITY
Russia
EU contribution
€ 106 800
Address
Leninskie Gory Main Building
119992 Moscow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alexander Rubtsov (Dr.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 369 328
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eran Vardi (Dr.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 142 800
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mario Ferrante (Mr.)
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Spain
EU contribution
€ 185 904
Address
Carrer Baldiri Reixac 10-12 Parc Scientific De Barcelona
08028 Barcelona
Activity type
Research Organisations
Administrative Contact
Margarida Corominas (Ms.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 302 160
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sanna-Maija Miettinen (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 229 900
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jill Blomstrand (Ms.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 264 960
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
XENTION LTD
United Kingdom
EU contribution
€ 209 268
Address
Iconix Park, London Road, Pampisford
CB22 3EG Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David Madge (Dr.)
UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 205 449,98
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jürgen Dreyer (Mr.)