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Identification and functional characterization of genetic cancer risk variants

Ziel

This Industry-Academia Partnership and Pathways (IAPP) joins three groups which have hitherto focused on different aspects of cancer genetics. deCODE genetics (deCODE) has recently identified several genetic risk variants that are associated with increased risk of cancer, including two distinct genetic prostate cancer risk variants on chromosome 8q24. The University of Torino (UNITO) group has identified a number of germline SNPs in signal transduction genes that are frequently mutated in tumors and the group has developed an innovative technology for knock-in of genetic variants in order to reconstruct genetic events in tumor progression. The Karolinska Institute (OP-KI) group has developed sophisticated tools for cytogenetic studies on tumors. The major objective of this proposal is to perform functional and cytogenetic analysis on several of the cancer risk variants identified by deCODE and UNITO. The major objectives of this proposal are 1) to discover and validate low-medium frequency polymorphisms that predispose to cancer, 2) to functionally validate the newly identified variants in human cells, 3) to identify biological properties associated with the prostate cancer risk alleles located at 8q24. Collaboration between deCODE, UNITO and OP-KI benefits all three partners since the capacities and technical skills are largely complementary. The collaboration is foreseen as an ongoing partnership aimed at elucidating the biological properties of genetic variants conferring risk of cancer.

Wissenschaftliches Gebiet

  • /Naturwissenschaften/Biowissenschaften/Genetik und Vererbung
  • /Medizin- und Gesundheitswissenschaften/Klinische Medizin/Onkologie/Krebs/Prostatakrebs

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2007-3-1-IAPP
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP)

Koordinator

ISLENSK ERFDAGREINING EHF
Adresse
Sturlugotu 8
101 Reykjavik
Island
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU-Beitrag
€ 784 442
Kontakt Verwaltung
Bjorgvin Richardsson (Mr.)

Beteiligte (2)

UNIVERSITA DEGLI STUDI DI TORINO
Italien
EU-Beitrag
€ 321 032
Adresse
Via Giuseppe Verdi 8
10124 Torino
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Maria Flavia Di Renzo (Dr.)
KAROLINSKA INSTITUTET
Schweden
EU-Beitrag
€ 394 301
Adresse
Nobels Vag 5
17177 Stockholm
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Riitta Perttunen-Elo (Ms.)