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Identification and functional characterization of genetic cancer risk variants

Objective

This Industry-Academia Partnership and Pathways (IAPP) joins three groups which have hitherto focused on different aspects of cancer genetics. deCODE genetics (deCODE) has recently identified several genetic risk variants that are associated with increased risk of cancer, including two distinct genetic prostate cancer risk variants on chromosome 8q24. The University of Torino (UNITO) group has identified a number of germline SNPs in signal transduction genes that are frequently mutated in tumors and the group has developed an innovative technology for knock-in of genetic variants in order to reconstruct genetic events in tumor progression. The Karolinska Institute (OP-KI) group has developed sophisticated tools for cytogenetic studies on tumors. The major objective of this proposal is to perform functional and cytogenetic analysis on several of the cancer risk variants identified by deCODE and UNITO. The major objectives of this proposal are 1) to discover and validate low-medium frequency polymorphisms that predispose to cancer, 2) to functionally validate the newly identified variants in human cells, 3) to identify biological properties associated with the prostate cancer risk alleles located at 8q24. Collaboration between deCODE, UNITO and OP-KI benefits all three partners since the capacities and technical skills are largely complementary. The collaboration is foreseen as an ongoing partnership aimed at elucidating the biological properties of genetic variants conferring risk of cancer.
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Coordinator

ISLENSK ERFDAGREINING EHF

Address

Sturlugata 8
101 Reykjavik

Iceland

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU Contribution

€ 784 442

Administrative Contact

Bjorgvin Richardsson (Mr.)

Participants (2)

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UNIVERSITA DEGLI STUDI DI TORINO

Italy

EU Contribution

€ 321 032

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 394 301

Project information

Grant agreement ID: 218071

Status

Closed project

  • Start date

    1 March 2008

  • End date

    29 February 2012

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 1 499 773

  • EU contribution

    € 1 499 773

Coordinated by:

ISLENSK ERFDAGREINING EHF

Iceland

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