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Plasmodium Vivax Infection in Pregnancy

Plasmodium Vivax Infection in Pregnancy

Objective

Malaria in pregnancy has been recently prioritised by the EC 7th Framework Program. In response, we propose to carry out a cohort observational study in pregnant women in 5 P. vivax endemic countries, broadly representing most of the world's infections. The Indian and Papua New Guinean endemic sites are included because of their important contribution to the global burden of vivax malaria; PNG has a high prevalence of asymptomatic P. vivax infections resembling P. falciparum infection in sub-Saharan Africa, and India contributes to nearly 80% of malaria cases in Southeast Asia. In Latin America, 3 countries are selected, Guatemala, Colombia and Brazil. In Guatemala P vivax is responsible for almost all malaria cases, in Colombia and Brazil it co-exists in different proportions with falciparum. Pregnant women will be enrolled at each site during routine antenatal care visits (ANC) and followed-up at the health facility until delivery or end of pregnancy. P. vivax malaria parasitaemia will be assessed at enrolment, at every contact with the health facility and at delivery. In a sub-sample of women, peripheral blood will be taken for immunological/molecular studies, and placental samples will be collected. To assess with precision the prevalence of infection (estimated to be around 4% on average) and to obtain sufficient number of pregnant women with P vivax infection to determine the impact on birthweight, 2000 pregnant women per site will be enrolled. Due to the likely low prevalence of infection in pregnancy, the number of pregnant women with P. vivax per site will probably not be enough to assess specific impact for each site, thus a multicentric study design will be used. Immunological analysis will be performed to unveil whether there are pregnancy-specific immune responses. Phenotypic and genotypic analyses of parasites from the placenta should reveal their adhesive properties and whether the accumulation of infected erythrocytes unique parasite population.
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Coordinator

FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA

Address

Carrer Rossello 149
08036 Barcelona

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 043 655

Administrative Contact

Mireia Piqueras (Dr.)

Participants (8)

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KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 305 562

ISTITUTO SUPERIORE DI SANITA

Italy

EU Contribution

€ 249 900

PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH - PNGIMR

Papua New Guinea

EU Contribution

€ 282 000

RAJASTHAN UNIVERSITY OF HEALTH SCIENCES JAIPUR

India

EU Contribution

€ 204 000

INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY

Italy

EU Contribution

€ 187 965

FUNDACAO DE MEDICINA TROPICAL DO AMAZONES

Brazil

EU Contribution

€ 264 483

UNIVERSIDAD DEL VALLE DE GUATEMALA

Guatemala

EU Contribution

€ 211 680

CENTRO INTERNACIONAL DE VACUNAS

Colombia

EU Contribution

€ 249 900

Project information

Grant agreement ID: 201588

Status

Closed project

  • Start date

    1 March 2008

  • End date

    31 August 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 928 460

  • EU contribution

    € 2 999 145

Coordinated by:

FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA

Spain

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