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PROteomics SPECification in Time and Space

Objective

Proteomics is a major new field in biomedical research, which deals with the large-scale identification and characterization of large groups of proteins, or “proteomes”. These can either be the components of a subcellular organelle or compartment, or even the entire protein complement of whole cells and tissues. Proteomics is essential in the functional annotation of the genome and in future attempts to build a quantitative, ‘systems-based’ description of cell biology. However, current ‘first generation’ proteomics approaches largely measure protein complexes and proteomes as homogeneous and static entities with little or no quantitative annotation. PROSPECTS (PROteomics SPECification in Time and Space) is a proposal by world leaders in this young discipline to make a major advance, both by developing much more powerful instrumentation and by applying novel proteomics methods that will allow us to annotate quantitatively the human proteome with respect to protein localization and dynamics. Complementary technologies, including mass spectrometry, cyro-electron microscopy and cell imaging will be applied in innovative ways to capture transient protein complexes and the spatial and temporal dimensions of entire proteomes. We will develop these new proteomics technologies in a generic fashion to maximize their utility to the wider biomedical community and we will generate comprehensive data sets that will foster many downstream functional studies. Our approaches will also generate unique insights into the molecular basis of multiple forms of human disease, specifically neurodegeneration and other diseases related to folding stress. The multidimensional data sets generated in PROSPECTS will be integrated using advanced data aggregation and machine learning, made available to the scientific community via annotated online public databases and used as a basis for a systems biological modelling of the human proteome, with spatial and temporal resolution within the cell.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /natural sciences/chemical sciences/analytical chemistry/mass spectrometry
  • /natural sciences/computer and information sciences/artificial intelligence/machine learning

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Address
Hofgartenstrasse 8
80539 Munich
Germany
Activity type
Other
EU contribution
€ 3 684 968
Administrative Contact
Anne Katrin Werenskiold (Dr.)

Participants (10)

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 1 035 800
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ruedi Aebersold (Prof.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE

Participation ended

United Kingdom
EU contribution
€ 111 408
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dawn Barker (Ms.)
SYDDANSK UNIVERSITET
Denmark
EU contribution
€ 800 500
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jens V. Kierkegaard (Dr.)
THERMO FISHER SCIENTIFIC (BREMEN) GMBH
Germany
EU contribution
€ 1 300 000
Address
Hanna Kunath Strasse 11
28199 Bremen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ernst Schröder (Dr.)
PROXEON BIOSYSTEMS A/S
Denmark
EU contribution
€ 601 600
Address
Staermosegardsvej 6
5230 Odense
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Hansen (Mr.)
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 799 446
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Stefan Pönisch (Mr.)
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 1 046 019
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
Administrative Contact
James Houston (Mr.)
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 809 162
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
åke Eriksson (Mr.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 1 000 000
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eran Vardi (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 588 588
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stewart Deakin (Mr.)