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PROteomics SPECification in Time and Space

Objective

Proteomics is a major new field in biomedical research, which deals with the large-scale identification and characterization of large groups of proteins, or “proteomes”. These can either be the components of a subcellular organelle or compartment, or even the entire protein complement of whole cells and tissues. Proteomics is essential in the functional annotation of the genome and in future attempts to build a quantitative, ‘systems-based’ description of cell biology. However, current ‘first generation’ proteomics approaches largely measure protein complexes and proteomes as homogeneous and static entities with little or no quantitative annotation. PROSPECTS (PROteomics SPECification in Time and Space) is a proposal by world leaders in this young discipline to make a major advance, both by developing much more powerful instrumentation and by applying novel proteomics methods that will allow us to annotate quantitatively the human proteome with respect to protein localization and dynamics. Complementary technologies, including mass spectrometry, cyro-electron microscopy and cell imaging will be applied in innovative ways to capture transient protein complexes and the spatial and temporal dimensions of entire proteomes. We will develop these new proteomics technologies in a generic fashion to maximize their utility to the wider biomedical community and we will generate comprehensive data sets that will foster many downstream functional studies. Our approaches will also generate unique insights into the molecular basis of multiple forms of human disease, specifically neurodegeneration and other diseases related to folding stress. The multidimensional data sets generated in PROSPECTS will be integrated using advanced data aggregation and machine learning, made available to the scientific community via annotated online public databases and used as a basis for a systems biological modelling of the human proteome, with spatial and temporal resolution within the cell.

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Address

Hofgartenstrasse 8
80539 Munich

Germany

Activity type

Other

EU Contribution

€ 3 684 968

Administrative Contact

Anne Katrin Werenskiold (Dr.)

Participants (10)

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EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 1 035 800

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 111 408

SYDDANSK UNIVERSITET

Denmark

EU Contribution

€ 800 500

THERMO FISHER SCIENTIFIC (BREMEN) GMBH

Germany

EU Contribution

€ 1 300 000

PROXEON BIOSYSTEMS A/S

Denmark

EU Contribution

€ 601 600

FUNDACIO CENTRE DE REGULACIO GENOMICA

Spain

EU Contribution

€ 799 446

UNIVERSITY OF DUNDEE

United Kingdom

EU Contribution

€ 1 046 019

KUNGLIGA TEKNISKA HOEGSKOLAN

Sweden

EU Contribution

€ 809 162

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

EU Contribution

€ 1 000 000

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 588 588

Project information

Grant agreement ID: 201648

Status

Closed project

  • Start date

    1 April 2008

  • End date

    31 March 2013

Funded under:

FP7-HEALTH

  • Overall budget:

    € 16 688 081,12

  • EU contribution

    € 11 777 491

Coordinated by:

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany