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Resolve Chronic Inflammation and Achieve Healthy Aging by Understanding Non-regenerative Repair

Resolve Chronic Inflammation and Achieve Healthy Aging by Understanding Non-regenerative Repair

Objective

RESOLVE has been outlined to better understand the regulatory networks that control the devel-opmental processes in organ repair and to identify mechanisms which cause the termination of regu-lar organ development leading to fibroproliferative wound healing. Fibroproliferative wound healing represents a major pathology in elderly people shifting regular organ development into progressive organ fibrosis with complete loss of organ function. Based on the identification of valuated molecu-lar targets of fibroproliferative repair, RESOLVE aims to create suitable treatment strategies to achieve healthy ageing in the elderly. In doing so, RESOLVE will create a significant impact on life quality of elderly people. RESOLVE’s outcomes will strengthen the competitiveness of European science and biotechnology industry and contribute to cost saving strategies in the health care sector. RESOLVE’s structured scientific approach combines as yet fragmented fields of research using model organisms which represent (a) different forms of wound healing, (b) different human diseases and (c) different genetic backgrounds, guaranteeing social and scientific relevance, modularity of re-search and the integration of existing biological knowledge, technical expertise and medical experi-ence. In addition, sequential generation of data during improvement or worsening ensures clinical relevance and leads to a stringent exploitation strategy. The sustainable outcomes of RESOLVE’s efforts will be: (A) the urgently needed diagnostic tool for fibroproliferative wound healing in various organs, (B) highly valuable transgenic animals offering test systems for fibroproliferative wound healing, and (C) a characterization of compounds capable of interfering with targets involved in fibroprolifera-tive repair.

Coordinator

MEDIZINISCHE UNIVERSITAET WIEN

Address

Spitalgasse 23
1090 Wien

Austria

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 816 568,44

Administrative Contact

Lutz-Henning Block (Prof.)

Participants (13)

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INTEGROMICS SL ITG

Spain

EU Contribution

€ 528 465

POLITECNICO DI TORINO

Italy

EU Contribution

€ 317 275

UNIVERSITA DEGLI STUDI DI VERONA

Italy

EU Contribution

€ 445 051,68

BIOTALENTUM TUDASFEJLESZTO KFT

Hungary

EU Contribution

€ 676 953

INSTYTUT MEDYCYNY WSI IM WITOLDA CHODZKI

Poland

EU Contribution

€ 399 920

BEN-GURION UNIVERSITY OF THE NEGEV

Israel

EU Contribution

€ 456 628

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

EU Contribution

€ 573 135

UNIVERSITY OF BRISTOL

United Kingdom

EU Contribution

€ 841 441

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH

Austria

EU Contribution

€ 2 427 159,88

BRIGITTE ROHNER

Austria

EU Contribution

€ 37 278,84

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

Germany

EU Contribution

€ 537 046

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 298 886

PUNKT INTERNATIONAL GMBH

Austria

EU Contribution

€ 333 906,16

Project information

Grant agreement ID: 202047

Status

Closed project

  • Start date

    1 April 2008

  • End date

    30 September 2013

Funded under:

FP7-HEALTH

  • Overall budget:

    € 14 173 960,86

  • EU contribution

    € 10 689 714

Coordinated by:

MEDIZINISCHE UNIVERSITAET WIEN

Austria

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