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Normalisation of immune reactivity in old age – from basic mechanisms to clinical application

Normalisation of immune reactivity in old age – from basic mechanisms to clinical application

Objective

When restoration of the immune response in older age is the target of basic and clinical research, boosting innate and adaptive immunity, e.g. by more efficient vaccination strategies, is the general approach. However, TOLERAGE has a fundamentally different focus, i.e. restoring the age-dependent decline of auto-tolerance that underlies the development of the paradigmatic age-associated diseases atherosclerosis (AS) and rheumatoid arthritis (RA). These diseases represent the major medical and socioeconomic burden in aging societies. They start earlier in life but become clinically manifest with increasing age. To reach this aim a consortium of ten partner groups was formed that have an outstanding track record in areas of immunology pertinent for this task. The work of TOLERAGE will focus on three major issues, viz. 1. Investigating basic principles of the induction of central and peripheral tolerance in mice against autoantigens, including heat shock protein 60 (HSP60) that has been shown to play a major role in the development of AS and RA. 2. Determination of the mediators of central and peripheral tolerance that are responsible for the T effector/T regulatory cell dysbalance in older age in general and in AS and RA in particular. 3. Translation of the results obtained in (a) and (b) into practical application for the prevention and treatment of AS and RA by appropriate vaccines. For all partners, important technical platforms will be available, including unique transgenic and knockout mouse strains, sophisticated models for in vitro and in vivo transfection of dendritic cells (DCs) and a well established Functional Genomics Facility.

Coordinator

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Address

Christoph Probst Platz 1
6020 Innsbruck

Austria

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 224 500

Administrative Contact

Georg Wick (Prof.)

Participants (9)

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KANTONSSPITAL ST. GALLEN

Switzerland

EU Contribution

€ 928 000

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 1 042 000

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

EU Contribution

€ 676 240

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 655 600

FONDAZIONE HUMANITAS PER LA RICERCA

Italy

EU Contribution

€ 786 000

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 803 591

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA

Italy

EU Contribution

€ 565 000

FUNCTIONAL GENOMICS CONSORTIUM

Italy

EU Contribution

€ 806 000

CENTER OF EXCELLENCE IN MEDICINE AND IT GMBH

Austria

EU Contribution

€ 250 000

Project information

Grant agreement ID: 202156

Status

Closed project

  • Start date

    1 April 2008

  • End date

    30 September 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 10 136 875,80

  • EU contribution

    € 7 736 931

Coordinated by:

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria