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Normalisation of immune reactivity in old age – from basic mechanisms to clinical application

Objective

When restoration of the immune response in older age is the target of basic and clinical research, boosting innate and adaptive immunity, e.g. by more efficient vaccination strategies, is the general approach. However, TOLERAGE has a fundamentally different focus, i.e. restoring the age-dependent decline of auto-tolerance that underlies the development of the paradigmatic age-associated diseases atherosclerosis (AS) and rheumatoid arthritis (RA). These diseases represent the major medical and socioeconomic burden in aging societies. They start earlier in life but become clinically manifest with increasing age. To reach this aim a consortium of ten partner groups was formed that have an outstanding track record in areas of immunology pertinent for this task. The work of TOLERAGE will focus on three major issues, viz. 1. Investigating basic principles of the induction of central and peripheral tolerance in mice against autoantigens, including heat shock protein 60 (HSP60) that has been shown to play a major role in the development of AS and RA. 2. Determination of the mediators of central and peripheral tolerance that are responsible for the T effector/T regulatory cell dysbalance in older age in general and in AS and RA in particular. 3. Translation of the results obtained in (a) and (b) into practical application for the prevention and treatment of AS and RA by appropriate vaccines. For all partners, important technical platforms will be available, including unique transgenic and knockout mouse strains, sophisticated models for in vitro and in vivo transfection of dendritic cells (DCs) and a well established Functional Genomics Facility.

Field of science

  • /medical and health sciences/health sciences/infectious disease/RNA virus/coronavirus
  • /medical and health sciences/basic medicine/immunology
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases/arteriosclerosis
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Address
Christoph Probst Platz 1
6020 Innsbruck
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 224 500
Administrative Contact
Georg Wick (Prof.)

Participants (9)

KANTONSSPITAL ST. GALLEN
Switzerland
EU contribution
€ 928 000
Address
Rorschacherstrasse 95
9007 St. Gallen
Activity type
Research Organisations
Administrative Contact
Burkhard Ludewig (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 1 042 000
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cecilia Tilly (Ms.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 676 240
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
Administrative Contact
Bettina Crispin (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 655 600
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Marianne Cottet (Ms.)
FONDAZIONE HUMANITAS PER LA RICERCA
Italy
EU contribution
€ 786 000
Address
Via Manzoni
20089 Rozzano
Activity type
Research Organisations
Administrative Contact
Danilo Petroni (Dr.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 803 591
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alexandra Dijk (Dr.)
UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy
EU contribution
€ 565 000
Address
Piazza Dell'ateneo Nuovo 1
20126 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anastasia Sguera (Dr.)
FUNCTIONAL GENOMICS CONSORTIUM
Italy
EU contribution
€ 806 000
Address
Piazza Della Scienza 2 Universita Degli Studi Milano
20126 Milan
Activity type
Research Organisations
Administrative Contact
Paola Castagnoli (Prof.)
CENTER OF EXCELLENCE IN MEDICINE AND IT GMBH
Austria
EU contribution
€ 250 000
Address
Karl Kapferer Strasse 5
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stefan Masser (Mr.)