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Genomic instability and genomic alterations in pre-cancerous lesions and/or cancer

Objective

GENINCA will address two tumor entities, for which we have good access to pre-malignant lesions and in which genomic instability is a common feature: colorectal and liver cancer. Colorectal cancer amounts to 13.2% of all incident cases of cancer, the second most common form of cancer, surpassed only by lung cancer (13.3%). Liver cancer accounts for about 2% of total cancers, however, the most common liver cancer, i.e. hepatocellular carcinoma (HCC), is among the most lethal form of cancer, and its incidence in Europe has been steadily rising over the last few decades. GENINCA represents a collaborative study of 8 academic and 3 industrial partners from 5 European countries. GENINCA will focus on exploring pre-cancerous and cancer lesions of the two aforementioned tumor entities and their respective microenvironment. As the recent identification of human colon-cancer initiating cells by one of our academic consortium members paves the way for completely new strategies for studying mechanisms of tumorigenesis, a particular focus of this grant proposal will be the detailed characterization of these cancer initiating stem cells. At present, it is still a matter of debate which genomic changes are already present in precursor lesions and whether these lesions already show genetic instability. We will therefore address the occurrence of genomic instability and explore their underlying mechanisms especially in pre-cancerous and early cancer lesions. This will be greatly facilitated by in vivo endomicroscopy approaches, sophisticated animal models and large-scale genomic and proteomic analyses. Furthermore, we will include an in-depth analysis of the corresponding microenvironment. As this represents a translational research effort, we expect to identify markers for novel therapeutic and/or preventative strategies, as well as to facilitate tumor diagnosis, prognosis, and monitoring.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/colorectal cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/liver cancer

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

MEDIZINISCHE UNIVERSITAT GRAZ
Address
Auenbruggerplatz 2
8036 Graz
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 264 483,48
Administrative Contact
Michael Speicher (Prof.)

Participants (13)

IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Italy
EU contribution
€ 276 600
Address
Via Adamello 16
20139 Milano
Activity type
Research Organisations
Administrative Contact
Raffaela Zoboli (Ms.)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 202 500
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Dr.)
CANCER RESEARCH UK LBG

Participation ended

United Kingdom
Address
St John Street 407 Angel Building
EC1V 4AD London
Activity type
Research Organisations
Administrative Contact
Ava Yeo (Dr.)
JOHANNES GUTENBERG-UNIVERSITAT MAINZ

Participation ended

Germany
EU contribution
€ 89 061,26
Address
Saarstrasse 21
55122 Mainz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Markus F. Neurath (Prof.)
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 247 200
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Klaus Pantel (Prof.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 276 525
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Jerome Galon (Dr.)
ORIDIS BIOMED FORSCHUNGS-UND ENTWICKLUNGS GMBH

Participation ended

Austria
EU contribution
€ 329 480,52
Address
Stiftingtalstrasse 3-5
8010 Graz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Wolfgang Senne
MOSAIQUES DIAGNOSTICS GMBH
Germany
EU contribution
€ 244 002
Address
Rotenburger Strasse 20
30659 Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Annika Fricke
BIOLUTION GMBH
Austria
EU contribution
€ 267 192
Address
Helmut Qualtinger Gasse 2/2
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Iris Grünert (Dr.)
UNIVERSITAET ULM
Germany
EU contribution
€ 322 132
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rainer Jerg
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 316 027
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Phil Clare (Dr.)
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 134 138,74
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katrin Faber (Dr.)
ORIDIS BIOMARKERS GMBH
Austria
EU contribution
€ 26 227
Address
Schonbrunner Strasse 218-A-4.04
1120 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Wolfgang Senne