Objective GENINCA will address two tumor entities, for which we have good access to pre-malignant lesions and in which genomic instability is a common feature: colorectal and liver cancer. Colorectal cancer amounts to 13.2% of all incident cases of cancer, the second most common form of cancer, surpassed only by lung cancer (13.3%). Liver cancer accounts for about 2% of total cancers, however, the most common liver cancer, i.e. hepatocellular carcinoma (HCC), is among the most lethal form of cancer, and its incidence in Europe has been steadily rising over the last few decades. GENINCA represents a collaborative study of 8 academic and 3 industrial partners from 5 European countries. GENINCA will focus on exploring pre-cancerous and cancer lesions of the two aforementioned tumor entities and their respective microenvironment. As the recent identification of human colon-cancer initiating cells by one of our academic consortium members paves the way for completely new strategies for studying mechanisms of tumorigenesis, a particular focus of this grant proposal will be the detailed characterization of these cancer initiating stem cells. At present, it is still a matter of debate which genomic changes are already present in precursor lesions and whether these lesions already show genetic instability. We will therefore address the occurrence of genomic instability and explore their underlying mechanisms especially in pre-cancerous and early cancer lesions. This will be greatly facilitated by in vivo endomicroscopy approaches, sophisticated animal models and large-scale genomic and proteomic analyses. Furthermore, we will include an in-depth analysis of the corresponding microenvironment. As this represents a translational research effort, we expect to identify markers for novel therapeutic and/or preventative strategies, as well as to facilitate tumor diagnosis, prognosis, and monitoring. Fields of science medical and health sciencesclinical medicineoncologyliver cancermedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologycolorectal cancer Keywords cancer early cancer lesions endomicroscpy approaches genomic instabilities proteomic analyses tumor diagnosis tumor monitoring tumor prognosis Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.4.1-3 - Genomic instability and genomic alterations in pre-cancerous lesions and/or cancer Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator MEDIZINISCHE UNIVERSITAT GRAZ EU contribution € 264 483,48 Address NEUE STIFTINGTALSTRASSE 6 8010 Graz Austria See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Administrative Contact Michael Speicher (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS Italy EU contribution € 276 600,00 Address VIA ADAMELLO 16 20139 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Raffaela Zoboli (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO SUPERIORE DI SANITA Italy EU contribution € 202 500,00 Address Viale Regina Elena 299 00161 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Rosa Maria Martoccia (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CANCER RESEARCH UK LBG Participation ended United Kingdom EU contribution No data Address 2 Redman Place E20 1JQ LONDON See on map Region London Inner London — West Camden and City of London Activity type Research Organisations Administrative Contact Ava Yeo (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JOHANNES GUTENBERG-UNIVERSITAT MAINZ Participation ended Germany EU contribution € 89 061,26 Address SAARSTRASSE 21 55122 Mainz See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Markus F. Neurath (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Germany EU contribution € 247 200,00 Address Martinistrasse 52 20251 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Higher or Secondary Education Establishments Administrative Contact Klaus Pantel (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 276 525,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Jerome Galon (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ORIDIS BIOMED FORSCHUNGS-UND ENTWICKLUNGS GMBH Participation ended Austria EU contribution € 329 480,52 Address Stiftingtalstrasse 3-5 8010 GRAZ See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Wolfgang Senne Links Contact the organisation Opens in new window Total cost No data MOSAIQUES DIAGNOSTICS GMBH Germany EU contribution € 244 002,00 Address ROTENBURGER STRASSE 20 30659 Hannover See on map Region Niedersachsen Hannover Region Hannover Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Annika Fricke Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOLUTION GMBH Austria EU contribution € 267 192,00 Address HELMUT QUALTINGER GASSE 2/2 1030 Wien See on map Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Iris Grünert (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET ULM Germany EU contribution € 322 132,00 Address HELMHOLTZSTRASSE 16 89081 Ulm See on map Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Rainer Jerg Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 316 027,00 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Phil Clare (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSKLINIKUM ERLANGEN Germany EU contribution € 134 138,74 Address MAXIMILIANSPLATZ 2 91054 Erlangen See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Katrin Faber (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ORIDIS BIOMARKERS GMBH Austria EU contribution € 26 227,00 Address SCHONBRUNNER STRASSE 218-A-4.04 1120 WIEN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Wolfgang Senne Links Contact the organisation Opens in new window Website Opens in new window Total cost No data