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micro-Fabrication of polymeric Lab-on-a-chip by Ultrafast lasers with Integrated optical Detection

micro-Fabrication of polymeric Lab-on-a-chip by Ultrafast lasers with Integrated optical Detection

Objective

Lab-on-chips (LOCs) are microsystems capable of manipulating small (micro to nanoliters) amounts of fluids in microfluidic channels with dimensions of tens to hundreds of micrometers: they have a huge application potential in many diverse fields, ranging from basic science (genomics and proteomics), to chemical synthesis and drug development, point-of-care medical analysis and environmental monitoring. Polymers are rapidly emerging as the material of choice for LOC production, due to the low substrate cost and ease of processing. Notwithstanding their potential, LOC commercial exploitation has been slow so far. Two breakthroughs that could promote LOC diffusion are: (i) a microfabrication technology with low-cost rapid prototyping capabilities; (ii) an integrated on-chip optical detection system.In this project we propose the use of femtosecond lasers as a novel highly flexible microfabrication platform for polymeric LOCs with integrated optical detection, for the realization of low-cost and truly portable biophotonic microsystems. Femtosecond laser processing is a direct, maskless fabrication technique enabling spatially selective three-dimensional material modification. It will be employed in different steps of the LOC production cycle: (i) rapid prototyping of the microfluidic chip using laser ablation or two-photon polymerization; (ii) direct fabrication of optical waveguides and integrated photonic components on the LOC for in situ optical sensing; (iii) master tool fabrication for mass production by replication techniques.The laser fabrication technology will enable to implement a variety of microfluidic LOCs with integrated photonic functionalities. In this project we concentrate on two prototypical applications in the fields of food quality and environmental sensing: LOCs for detection of mycotoxins in animal feeds and LOCs for water screening to detect bacteria and heavy ions contamination.

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE

Address

Piazzale Aldo Moro 7
00185 Roma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 433 563

Administrative Contact

ROBERTO OSELLAME (Dr.)

Participants (10)

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CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT

Switzerland

EU Contribution

€ 201 814

LZH LASER ZENTRUM HANNOVER E.V.

Germany

EU Contribution

€ 478 356

INSTITUT FUER MIKROTECHNIK MAINZ GMBH

Germany

EU Contribution

€ 462 070

MICROFLUIDIC CHIPSHOP GMBH

Germany

EU Contribution

€ 251 471

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 377 200

AGROLABO S.P.A.

Italy

EU Contribution

€ 215 520

POLITECNICO DI MILANO

Italy

EU Contribution

€ 303 876

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 476 130

CONSERVATOIRE NATIONAL DES ARTS ET METIERS

France

ECOLE NORMALE SUPERIEURE DE CACHAN

France

Project information

Grant agreement ID: 224205

Status

Closed project

  • Start date

    1 June 2008

  • End date

    31 October 2011

Funded under:

FP7-ICT

  • Overall budget:

    € 4 490 538

  • EU contribution

    € 3 200 000

Coordinated by:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy