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Encoded Cellular Synthesis of Unnatural Biopolymers

Objective

We are building a parallel and independent (orthogonal) translational machinery for the encoded biosynthesis of unnatural polymers in living cells. The orthogonal translation system has many potential applications beyond those possible with the natural translation system: I propose to use it: 1) To expand the chemical scope of monomers that can be polymerized by the ribosome in living cells, allowing the incorporation of monomers with unnatural backbones into proteins; 2) To increase the efficiency of in vivo unnatural amino acid mutagenesis via amber suppression, so that no truncated protein is produced and multi-site incorporation of unnatural amino acids is possible; 3) To create probes of protein function for use in vivo; 4) To free numerous codons for simultaneous encoding of multiple distinct unnatural monomers, and to experimentally explore alternate genetic codes; 5) To explore the evolution of encoded unnatural polymers toward new cellular functions.
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Principal Investigator

Jason William Karl Chin (Dr.)

Host institution

MEDICAL RESEARCH COUNCIL

Address

North Star Avenue Polaris House 2 Floor David Phillips Building
Sn2 1fl Swindon

United Kingdom

Activity type

Research Organisations

EU Contribution

€ 1 782 918

Principal Investigator

Jason William Karl Chin (Dr.)

Administrative Contact

Elizabeth Cutler (Ms.)

Beneficiaries (1)

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MEDICAL RESEARCH COUNCIL

United Kingdom

EU Contribution

€ 1 782 918

Project information

Grant agreement ID: 200583

Status

Closed project

  • Start date

    1 January 2009

  • End date

    31 December 2014

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 782 918

  • EU contribution

    € 1 782 918

Hosted by:

MEDICAL RESEARCH COUNCIL

United Kingdom