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Genomic stability -chromosome segregation and repair

Genomic stability -chromosome segregation and repair

Objective

The eukaryotic genome combines a highly dynamic nature with stable transmission of genetic information from mother to daughter cells. This is achieved by a plethora of protein networks regulating processes such as chromosome duplication, segregation and repair. The principal aim of our research is to determine the molecular interplay between chromosome segregation and repair. Accurate execution of these two events is crucial for the maintenance of genome stability, which in turn is essential for life. Additionally, erroneous segregation or repair leads to chromosomal aberrations that are linked to tumor formation and human developmental syndromes. Thus, our investigations are not only crucial in a basic research perspective, but important also for the understanding of the causes of human disease. The research is based on the budding yeast model system, and combines genome-wide analysis of protein-chromosome interactions with cell-based experimental systems. Our investigations have until now revealed that chromosome segregation and repair are directly linked through two evolutionary conserved SMC (Structural Maintenance of Chromosomes) protein complexes, Cohesin and the Smc5/6 complex. The project now further explores the molecular details of this connection, bringing light into this unexplored area of research, and deciphering the cellular defense against genomic alterations connected to cancer and developmental diseases.
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Principal Investigator

Camilla Björkegren Sjögren (Dr.)

Host institution

KAROLINSKA INSTITUTET

Address

Nobels Vag 5
17177 Stockholm

Sweden

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 900 000

Principal Investigator

Camilla Björkegren Sjögren (Dr.)

Administrative Contact

Riitta Ljungström (Ms.)

Beneficiaries (1)

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KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 900 000

Project information

Grant agreement ID: 201214

Status

Closed project

  • Start date

    1 September 2008

  • End date

    31 August 2013

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 900 000

  • EU contribution

    € 900 000

Hosted by:

KAROLINSKA INSTITUTET

Sweden