CORDIS
EU research results

CORDIS

English EN
The role of RNA silencing in immunity and development in eukaryotes

The role of RNA silencing in immunity and development in eukaryotes

Objective

RNA silencing is a pan-eukaryotic gene regulation process that involves RNA molecules 19-30nt in length. These molecules are produced by RNAse-III proteins in the Dicer family and engage into sequence-specific regulation of complementary DNA or RNA upon their incorporation into effector complexes. RNA silencing serves essential roles in biology but the molecular bases of its mechanisms are still poorly understood. One major aspect of the proposed project is to decipher genetically the composition of RNA silencing effector complexes and to understand how those complexes orchestrate the regulation of fundamental processes involved in cell differentiation, notably the process of dosage compensation during chromosome X inactivation in mammals. The second aspect is part of our ongoing efforts to understand the implication of small RNAs in plant and animal innate immunity, their impact on pathogen’s fitness and evolution, and how pathogens counteract small RNA-directed immune pathways.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Principal Investigator

Olivier Voinnet (Dr.)

Host institution

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Address

Raemistrasse 101
8092 Zuerich

Switzerland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 375 670

Principal Investigator

Olivier Voinnet (Dr.)

Administrative Contact

Olivier Voinnet (Prof.)

Beneficiaries (2)

Sort alphabetically

Sort by EU Contribution

Expand all

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 375 670

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 524 330

Project information

Grant agreement ID: 210890

Status

Closed project

  • Start date

    1 August 2008

  • End date

    31 July 2012

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 900 000

  • EU contribution

    € 900 000

Hosted by:

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland