Objective RNA silencing is a pan-eukaryotic gene regulation process that involves RNA molecules 19-30nt in length. These molecules are produced by RNAse-III proteins in the Dicer family and engage into sequence-specific regulation of complementary DNA or RNA upon their incorporation into effector complexes. RNA silencing serves essential roles in biology but the molecular bases of its mechanisms are still poorly understood. One major aspect of the proposed project is to decipher genetically the composition of RNA silencing effector complexes and to understand how those complexes orchestrate the regulation of fundamental processes involved in cell differentiation, notably the process of dosage compensation during chromosome X inactivation in mammals. The second aspect is part of our ongoing efforts to understand the implication of small RNAs in plant and animal innate immunity, their impact on pathogen’s fitness and evolution, and how pathogens counteract small RNA-directed immune pathways. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological scienceszoologymammalogynatural sciencesbiological sciencesgeneticschromosomes Keywords RNA induced silencing complex X chromosome differentiation miRNA siRNA virus viruses Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-LS1 - ERC Starting Grant - Molecular and Structural Biology and Biochemistry Call for proposal ERC-2007-StG See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Host institution EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EU contribution € 375 670,00 Address Raemistrasse 101 8092 Zuerich Switzerland See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Olivier Voinnet (Prof.) Principal investigator Olivier Voinnet (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 375 670,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Olivier Voinnet (Prof.) Principal investigator Olivier Voinnet (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Participation ended France EU contribution € 524 330,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Denis Fix (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
