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Markers for emphysema versus airway disease in COPD

Objective

COPD is characterized by emphysema (destruction of the lung alveoli) and airway disease (inflammation and thickening of the bronchial wall) both of which lead to airway obstruction. These two features co-exist in most patients but some patients present with only emphysema (E) or only airway disease (A). The aim of the project is to identify markers specific to E and A of COPD. Our hypothesis is that the mechanisms leading to these pathologies are distinct with respect to the type of inflammatory response and in terms of genetic predisposition. The differential pathogenesis for emphysema (E) and inflammatory airway disease (A) entails that in the two forms of COPD are linked to different markers at the DNA, RNA and protein level. Using computer tomography (CT) scans for selection of patients with emphysema only and airway disease only, we will obtain material from lung (leukocytes, bronchial cells) and blood (leukocytes), and will analyse elements of gene expression (SNP array, transcriptome). Data analysis will be done for E versus A (EvA) and versus a control cohort leading to identification of markers linked specifically to either E or A. These markers will be elements involved in a differential pathogenesis for the different disease processes in COPD. They can be used for diagnostic approaches and as therapeutic targets.
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Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Address

Ingolstadter Landstrasse 1
85764 Neuherberg

Germany

Activity type

Research Organisations

EU Contribution

€ 563 593

Administrative Contact

Juergen Ertel (Dr.)

Participants (14)

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UNIVERSITY OF LEICESTER

United Kingdom

EU Contribution

€ 270 600

UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NATIONAL HEALTH SERVICE TRUST

United Kingdom

EU Contribution

€ 185 625

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 194 197

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 6 700

UNIVERSITA DEGLI STUDI DI FERRARA

Italy

EU Contribution

€ 178 136

INSTYTUT GRUZLICY I CHOROB PLUC

Poland

EU Contribution

€ 147 600

ORSZAGOS KORANYI TBE ES PULMONOLOGIAI INTEZET

Hungary

EU Contribution

€ 137 600

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 469 866

EUROPEAN RESPIRATORY SOCIETY

Switzerland

EU Contribution

€ 1 774

PHILIPPS UNIVERSITAET MARBURG

Germany

EU Contribution

€ 190 200

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

EU Contribution

€ 190 200

P & M VENGE AB

Sweden

EU Contribution

€ 18 000

UNIVERSITAETSKLINIKUM FREIBURG

Germany

EU Contribution

€ 191 000

FUNDACIO PARC CIENTIFIC DE BARCELONA

Spain

EU Contribution

€ 238 934

Project information

Grant agreement ID: 200605

Status

Closed project

  • Start date

    1 October 2008

  • End date

    31 March 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 952 828,80

  • EU contribution

    € 2 984 025

Coordinated by:

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany