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Metagenomics of the Human Intestinal Tract

Objective

A detailed understanding of human biology will require not only knowledge of the human genome but also of the human metagenome, defined here as the ensemble of the genomes of human-associated microorganisms. Our proposal focuses on the microorganisms of the gut, which are particularly abundant and complex and have an important role for human health and well-being. We shall implement and integrate the following activities: (i) creation of a reference set of genes and genomes of intestinal microbes, using high fidelity metagenomic sequencing and full genome sequencing of selected bacterial species; (ii) creation of the generic tools, based on the high density DNA arrays and novel ultra-high throughput re-sequencing techniques, to study the variation of human gut microbiota; (iii) use of the tools to search for correlations between the genes present in the gut microbiota and disease, focusing on the inflammatory bowel disease and obesity, the two pathologies of increasing social relevance in Europe; (iv) study of the genes correlated with the disease, both in terms of their function in microbes and their effect on the host, with the focus on host-microbe interactions; (v) development of an informatics resource to store and organize the heterogeneous information generated within the project, such as gene and genome sequences, gene frequencies in healthy and sick individuals or gene functions and also enriched by information relevant to human gut microbiota from the outside of the project; (vi) creation of the bioinformatics tools to carry out the meta-analysis of the information; (vii) creation of an interface with the stakeholders, including an international board to promote cooperation and coordination in the human metagenome field, and general public. Our project will place Europe in a leading position in this field and open avenues to modulate human gut microbiota in a reasoned way, enabling to optimize the health and wellbeing of any individual.

Field of science

  • /medical and health sciences/basic medicine/medical genetics
  • /natural sciences/biological sciences/genetics and heredity/dna
  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Address
Rue De L'universite 147
75338 Paris Cedex 07
France
Activity type
Research Organisations
EU contribution
€ 2 289 017,65
Administrative Contact
François Chambelin (Mr.)

Participants (15)

DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 1 464 910
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karen Bue Bitsch (Ms.)
DANONE RESEARCH SAS
France
Address
Route Departementale 128
91767 Palaiseau
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrice Lecoeuche (Mr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 1 434 954,15
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Keith Williamson (Mr.)
INSTITUT CATALA DE LA SALUT
Spain
EU contribution
€ 417 000
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Juan E. Feliu (Dr.)
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
EU contribution
€ 392 000
Address
Via Filodrammatici 10
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ilaria Foti (Ms.)
NOVO NORDISK A/S
Denmark
EU contribution
€ 295 000
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Oluf Pedersen (Prof.)
SYDDANSK UNIVERSITET

Participation ended

Denmark
EU contribution
€ 418 429
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jens Kierkegaard (Mr.)
UCB PHARMA SA
Spain
Address
Avenida De Barcelona 239
08750 Molins De Rei
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ellen Caldwell (Ms.)
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 622 722
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Willem Meindert De Vos (Prof.)
GENOME RESEARCH LIMITED
United Kingdom
EU contribution
€ 680 885,20
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
Administrative Contact
Julian Parkhill (Dr.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 1 854 000
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Jean Weissenbach (Dr.)
Beijing Genome Institute

Participation ended

China
Address
Beitucheng West Road 7
100029 Beijing
Activity type
Research Organisations
Administrative Contact
Huanming Yang (Prof.)
Beijing Genomics Institute at Shenzhen
China
EU contribution
€ 459 511
Address
Beishan Industrial Zone
518083 Shenzhen
Activity type
Research Organisations
Administrative Contact
Huanming Yang (Prof.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 1 071 571
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
MERIEUX ALLIANCE SA
France
Address
Rue Bourgelat 17
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martine Cattelain (Ms.)