CORDIS
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Large scale interactions in brain networks and their breakdown in brain diseases

Objective

The long-term goal of this project is to understand how neuronal assemblies exchange information (functional or neuronal communication), and how variability in neuronal communication explains variability in behavioural performance, both in the intact and injured brain. Communication involves temporal interactions between neuronal assemblies either locally within an area or large-scale between areas. We concentrate on large-scale interaction that occur at two different temporal scales: 'slow' (<0.1 Hz) fluctuations of the blood oxygen level dependent (BOLD) signal easily measured with functional magnetic resonance imaging (fMRI), and 'fast' (1-150 Hz) neuronal oscillations measured at high (multi-unit activity (MUA), local field potential (LFP)) or low (electroencephalography, EEG; magnetoencephalography, MEG) spatial resolution. We wish to demonstrate that these two phenomena are mechanistically linked and are behaviorally significant. A potentially important clinical application is the development of easy-to-use diagnostic measures of neuronal communication for many brain diseases such as stroke, traumatic head injury, multiple sclerosis, and Alzheimer's disease.
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Coordinator

UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA

Address

Via Dei Vestini 31
66013 Chieti

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 549 280

Administrative Contact

Maurizio Corbetta (Prof.)

Participants (7)

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KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 449 999

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

EU Contribution

€ 445 261

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 191 200

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 399 964

FUNDACIO BARCELONA MEDIA

Spain

EU Contribution

€ 288 138

USTAV INFORMATIKY AV CR

Czechia

EU Contribution

€ 254 200

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Germany

EU Contribution

€ 400 200

Project information

Grant agreement ID: 200728

Status

Closed project

  • Start date

    1 March 2008

  • End date

    28 February 2011

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 933 811

  • EU contribution

    € 2 978 242

Coordinated by:

UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA

Italy

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