Objectif It is increasingly evident that in-utero exposure to environmental chemicals (ECs), including endocrine disrupting compounds (EDCs) and heavy metals, disturbs reproductive development in wildlife, domestic species and humans. Current thinking is that exposure to ECs is part of the mechanism driving increasing incidences of reproductive dysfunction in males and females, the latter characterised by statistics such as the 2% annual increase in EU breast cancer rates. Studies on a wide range of ECs, including phthalates, PCBs and dioxins, suggest the whole female reproductive tract is sensitive to chemical perturbation. However, many studies have focused on single or small numbers of ECs on short-lived rodent species at high doses. These exposure modalities have no relationship with normal human exposure. We will use a long-lived species, mono-ovulating, the sheep, with a pattern of gestational development similar to humans, exposed long-term to a broad range of ECs at low/environmental concentrations. This will provide a real-life model for human exposure. We will investigate follicle formation, oocyte maturation, ovaries, uteri and mammary glands in fetal sheep exposed in-utero and in adult offspring. Selected ECs preferentially concentrated in fetal tissues will be investigated using sheep and mouse models, the latter primarily for mechanistic studies. Our scale of investigation will encompass epigenetic right up to transgenerational effects of exposure and will utilise cutting-edge methodologies including proteomics, transcriptomics and organotypic cultures. To ensure we understand the link with human reproductive development, we will investigate EC-sensitive genes and proteins identified in the animal models in normal second trimester human fetuses and culture of fetal human ovaries with ECs identified as potential key chemicals in the animal models. This study will establish the potential risks of environmental chemicals on human female reproductive development. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicineoncologybreast cancernatural sciencesearth and related environmental sciencesenvironmental sciencespollutionmedical and health sciencesclinical medicineembryology Mots‑clés development endocrine disruption environmental chemicals female reproductive tract in-utero exposure Programme(s) FP7-ENVIRONMENT - Specific Programme "Cooperation": Environment (including Climate Change) Thème(s) ENV.2007.1.2.1.2. - Environmental factors and their impact on reproduction and development Appel à propositions FP7-ENV-2007-1 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN Contribution de l’UE € 644 578,00 Adresse KING'S COLLEGE REGENT WALK AB24 3FX ABERDEEN Royaume-Uni Voir sur la carte Région Scotland North Eastern Scotland Aberdeen City and Aberdeenshire Type d’activité Higher or Secondary Education Establishments Contact administratif Frederick Stevenson-Robb (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France Contribution de l’UE € 514 852,00 Adresse 147 RUE DE L'UNIVERSITE 75007 Paris Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Angelo Trussardi (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG Allemagne Contribution de l’UE € 476 676,00 Adresse UNIVERSITATSPLATZ 10 6108 Halle Voir sur la carte Région Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Type d’activité Higher or Secondary Education Establishments Contact administratif Manfred Jank (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE UNIVERSITY OF NOTTINGHAM Royaume-Uni Contribution de l’UE € 632 292,00 Adresse University Park NG7 2RD Nottingham Voir sur la carte Région East Midlands (England) Derbyshire and Nottinghamshire Nottingham Type d’activité Higher or Secondary Education Establishments Contact administratif Paul Cartledge (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI MILANO Italie Contribution de l’UE € 381 462,00 Adresse Via Festa Del Perdono 7 20122 Milano Voir sur la carte Région Nord-Ovest Lombardia Milano Type d’activité Higher or Secondary Education Establishments Contact administratif Donatella Sacchelli (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE MACAULAY LAND USE RESEARCH INSTITUTE Royaume-Uni Contribution de l’UE € 273 503,00 Adresse Craigiebuckler 8, A1a AB15 8QH ABERDEEN Voir sur la carte Type d’activité Research Organisations Contact administratif Carold Bisset (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée