Cel The growing awareness of the pressing need for greener, more sustainable technologies has focused attention on the use of atom efficient catalytic methodologies for the manufacture of fine chemicals and pharmaceuticals. The use of alternative reaction solvents such as supercritical fluids or fluorous biphasic systems that are readily recycled has therefore become the focus of significant research that could circumvent the problems associated with many of the traditional volatile organic solvents. Thus novel and effective methods for reactor design, enzyme recovery and recycling are receiving increasing attention. New approaches to tackling these issues form the main objectives of this Proposal. The use of immobilized enzymes in the form of Cross-Linked Enzyme Aggregates (CLEAs) in supercritical carbon dioxide (scCO2) or fluorous reaction media including the use of ‘combi-CLEAs’, two enzymes that catalyse complementary reactions for one-pot two-step conversions in both batch and continuous reactions forms one major task. The use of hydrophobic-ion pairing of enzymes with perfluorinated surfactants to solubilise them in scCO2 and fluorous solvents and thus allow homogeneous catalysis to occur is the focus of the second task. The oxidases catalyzing the mild and clean formation of H2O2 from dioxygen will be investigated. This H2O2 will then be used in epoxidation and Baeyer-Villiger chemistry, either on the product of the oxidase reaction or a second substrate. Enzyme catalyzed polymerization reactions in scCO2 and fluorous solvents will also be investigated including the formation of perfluorinated polymers that may have unique physical and chemical properties. This fellowship will bring together strong research background of Dr. I. Lapenaite with excellent training opportunities at the University of Nottingham. This team aims to deliver significant breakthroughs in the development of new environmentally sustainable processing of organic materials. Dziedzina nauki engineering and technologyenvironmental engineeringwaste managementwaste treatment processesrecyclingmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencespolymer sciencesnatural scienceschemical sciencescatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Słowa kluczowe CLEA biocatalysis clean synthesis enzyme epoxidation immobilization supercritical fluids Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Zaproszenie do składania wniosków FP7-PEOPLE-2007-2-1-IEF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IEF - Intra-European Fellowships (IEF) Koordynator THE UNIVERSITY OF NOTTINGHAM Wkład UE € 169 957,94 Adres University Park NG7 2RD Nottingham Zjednoczone Królestwo Zobacz na mapie Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Martyn Poliakoff (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych