Objetivo The vision of putting a lab on a chip has far reaching implications for biological research. Microfluidic systems can now be built that - for example in past research by the applicant - can be used for protein crystallisation with only minute amount of precious proteins. A second challenge is to carry out functional biological assays on a chip. Such assays are used in high-throughput screening, e.g. for novel drug molecule or protein mutants with improved properties for directed evolution of functional proteins. In each case the economy of the assay system (total numbers screened, speed, reliability, quality of the kinetic readout) will crucially determine the success of this combinatorial approach. Water-in-oil droplets within microfluidic channels have the potential to serve as isolated reaction compartments, just like natural cells. Their femtolitre volumes minimise sample consumption and eliminate dispersion of substrates or products. To this end the candidate will build novel microfluidic devices that incoproprate the principle of in vitro compartementalisation. The fabrication of this device, and especially the integration of the various components is a significant challenge. Ámbito científico natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Palabras clave directed evolution in vitro compartmentalisation microfluidics Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) PEOPLE-2007-4-2.IIF - Marie Curie Action: "International Incoming Fellowships" Convocatoria de propuestas FP7-PEOPLE-2007-4-2-IIF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IIF - International Incoming Fellowships (IIF) Coordinador THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Aportación de la UE € 178 874,06 Dirección TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Reino Unido Ver en el mapa Región East of England East Anglia Cambridgeshire CC Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Wendy Holman (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
