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Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicine

Objective

A Europe-wide consortium of experimental biologists, biomathematicians, biostatisticians, computer scientists and clinical scientists will team up to approach cell death pathways in health and disease, placing particular emphasis on cancer and AIDS. The consortium will create a unique database integrating existing and accumulating knowledge on lethal signal transduction pathways leading to apoptosis or non-apoptotic (necrotic, autophagic, mitotic) cell death, perform data mining to integrate system-wide analyses on cell death (genome, epigenome, transcriptome, proteome, lipidome data), and use high-throughput methods (“omics”, CHiP-chip and genome-wide siRNA screens) for the experimental exploration of death pathways in human cell lines in vitro and in relevant disease models (in vitro in human cells and in vivo in mice and Drosophila). In addition, the consortium will establish mathematical models of lethal pathways to devise algorithms that predict apoptosis susceptibility and resistance, obtain data (genome, transcriptome, proteome, lipidome) on clinical samples (cancer cell lines, cancer tissues, serum, and blood samples) and perform biostatistical analyses on them in order to demonstrate the contribution of apoptotic process in human cancers and AIDS. Then, the consortium will integrate the knowledge into mathematical models for the optimal interpretation of clinical data, aiming at optimal diagnostic and prognostic performance as well as at the identification of possible therapeutic targets for the treatment of cancer and AIDS.

Field of science

  • /medical and health sciences/health sciences/public and environmental health/epidemics prevention/modeling of disease spread

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 473 182,39
Administrative Contact
Per-Olof Larsson (Mr.)

Participants (23)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 860 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Audrey Laurent (Ms.)
INSTITUT CURIE
France
EU contribution
€ 597 697,60
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
Administrative Contact
Corinne Cumin (Ms.)
ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
EU contribution
€ 580 000
Address
Via Portuense, 292
00149 Roma
Activity type
Research Organisations
Administrative Contact
Cinzia Bomboni (Dr.)
VIB VZW
Belgium
EU contribution
€ 530 000
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Wim Goemaere (Mr.)
UNIVERSITAET ULM

Participation ended

Germany
EU contribution
€ 114 846,06
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 480 000
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nicolas Fasel (Prof.)
KRAEFTENS BEKAEMPELSE
Denmark
EU contribution
€ 470 000
Address
Strandboulevarden 49
2100 Koebenhavn
Activity type
Research Organisations
Administrative Contact
David Mollerup (Mr.)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 389 687,20
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Activity type
Research Organisations
Administrative Contact
Katel Schaeffer (Ms.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 530 000
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
TEKNOLOGIAN TUTKIMUSKESKUS VTT
Finland
EU contribution
€ 380 000
Address
Tekniikantie 4 A
02044 VTT Espoo
Activity type
Research Organisations
Administrative Contact
Jaana Heino (Ms.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 390 000
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
Administrative Contact
Bettina Crispin (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 363 059
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Keith Williamson (Mr.)
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 300 000
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lea Pais (Ms.)
Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 787 692
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Knepper-Nicolai (Dr.)
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Austria
EU contribution
€ 470 000
Address
Dr Bohrgasse 3
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tanja Winkler (Ms.)
SYDDANSK UNIVERSITET
Denmark
EU contribution
€ 459 700
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jens V. Kierkegaard (Mr.)
ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland
EU contribution
€ 270 000
Address
Saint Stephen's Green 123
2 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Barry Mcgowan (Mr.)
UNIVERSITAET GRAZ
Austria
EU contribution
€ 270 004
Address
Universitatsplatz 3
8010 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Madeo (Prof.)
UNIVERSITE LYON 1 CLAUDE BERNARD
France
EU contribution
€ 300 000
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Javier Olaiz (Dr.)
UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI
Italy
EU contribution
€ 269 980
Address
Viale Abramo Lincoln 5
81100 Caserta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Annunziata Valente (Dr.)
MEDICEL OY

Participation ended

Finland
EU contribution
€ 193 798,61
Address
Haartmaninkatu 8
00290 Helsinki
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christophe Roos (Dr.)
KLINIKUM DER JOHANN WOLFGANG VON GOETHE UNIVERSITAET
Germany
EU contribution
€ 302 654
Address
Theodor Stern Kai 7
60596 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kseniya Polozheyeva (Ms.)
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 217 699,14
Address
Boulevard Charles Livon 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Celine Damon (Ms.)