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Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicine

Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicine

Objective

A Europe-wide consortium of experimental biologists, biomathematicians, biostatisticians, computer scientists and clinical scientists will team up to approach cell death pathways in health and disease, placing particular emphasis on cancer and AIDS. The consortium will create a unique database integrating existing and accumulating knowledge on lethal signal transduction pathways leading to apoptosis or non-apoptotic (necrotic, autophagic, mitotic) cell death, perform data mining to integrate system-wide analyses on cell death (genome, epigenome, transcriptome, proteome, lipidome data), and use high-throughput methods (“omics”, CHiP-chip and genome-wide siRNA screens) for the experimental exploration of death pathways in human cell lines in vitro and in relevant disease models (in vitro in human cells and in vivo in mice and Drosophila). In addition, the consortium will establish mathematical models of lethal pathways to devise algorithms that predict apoptosis susceptibility and resistance, obtain data (genome, transcriptome, proteome, lipidome) on clinical samples (cancer cell lines, cancer tissues, serum, and blood samples) and perform biostatistical analyses on them in order to demonstrate the contribution of apoptotic process in human cancers and AIDS. Then, the consortium will integrate the knowledge into mathematical models for the optimal interpretation of clinical data, aiming at optimal diagnostic and prognostic performance as well as at the identification of possible therapeutic targets for the treatment of cancer and AIDS.
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Coordinator

KAROLINSKA INSTITUTET

Address

Nobels Vag 5
17177 Stockholm

Sweden

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 473 182,39

Administrative Contact

Per-Olof Larsson (Mr.)

Participants (23)

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INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 860 000

INSTITUT CURIE

France

EU Contribution

€ 597 697,60

ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO

Italy

EU Contribution

€ 580 000

VIB

Belgium

EU Contribution

€ 530 000

UNIVERSITAET ULM

Germany

EU Contribution

€ 114 846,06

UNIVERSITE DE LAUSANNE

Switzerland

EU Contribution

€ 480 000

KRAEFTENS BEKAEMPELSE

Denmark

EU Contribution

€ 470 000

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

France

EU Contribution

€ 389 687,20

WEIZMANN INSTITUTE OF SCIENCE

Israel

EU Contribution

€ 530 000

TEKNOLOGIAN TUTKIMUSKESKUS VTT

Finland

EU Contribution

€ 380 000

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

EU Contribution

€ 390 000

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 363 059

TEL AVIV UNIVERSITY

Israel

EU Contribution

€ 300 000

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 787 692

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH

Austria

EU Contribution

€ 470 000

SYDDANSK UNIVERSITET

Denmark

EU Contribution

€ 459 700

ROYAL COLLEGE OF SURGEONS IN IRELAND

Ireland

EU Contribution

€ 270 000

UNIVERSITAET GRAZ

Austria

EU Contribution

€ 270 004

UNIVERSITE LYON 1 CLAUDE BERNARD

France

EU Contribution

€ 300 000

UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI

Italy

EU Contribution

€ 269 980

MEDICEL OY

Finland

EU Contribution

€ 193 798,61

KLINIKUM DER JOHANN WOLFGANG VON GOETHE UNIVERSITAET

Germany

EU Contribution

€ 302 654

UNIVERSITE D'AIX MARSEILLE

France

EU Contribution

€ 217 699,14

Project information

Grant agreement ID: 200767

Status

Closed project

  • Start date

    1 February 2008

  • End date

    31 January 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 14 780 447,52

  • EU contribution

    € 11 000 000

Coordinated by:

KAROLINSKA INSTITUTET

Sweden