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Systems Biology of T-cell Activation in Health and Disease

Objective

T-cell activation, whether induced by pathogens or auto-antigens, is a complex process relying on multiple layers of tightly controlled intracellular signalling modules that form an intricate network. Defects in this network can cause severe and chronic disorders such as autoimmune diseases. Although 5% of the population suffer from these diseases, only a few therapeutic treatments are available. To a large extent this is attributed to the lack of systems-level insights, which would provide concepts of how to modulate T-cell activation. The SYBILLA project groups 14 partners from 9 different EU countries, including 3 SMEs. Through a multidisciplinary effort it aims to understand at the systems’ level, how T-cells discriminate foreign from auto-antigens. Towards this goal, a transgenic mouse system will be used as a tractable physiological model. Data will be validated in human T-cells and a humanised mouse model for multiple sclerosis. SYBILLA will develop technological and mathematical tools to generate and integrate high-density quantitative data describing T-cell activation. Proteomics, transcriptomics, metabolomics, imaging and multiplexed biochemical techniques will be applied to obtain holistic maps of T-cell signalling networks and to achieve a quantitative understanding of the network and its regulation in response to different inputs. Building upon our existing network model, constant iterations will be used to develop more robust dynamic models to describe the network’s response to perturbations. This will culminate in the generation of a Virtual T-Cell, allowing computer simulation to refine the predictability of physiological and pathophysiological reactions. SYBILLA’s impact on EU biopharmaceutical competitiveness will be enormous through identification of new pharmacologic targets, optimised prediction of immunomodulatory drug efficacy, discovery of new concerted biomarkers and improvement of personalised medication for treating autoimmune diseases.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug
  • /medical and health sciences/basic medicine/neurology/multiple sclerosis
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Address
Fahnenbergplatz
79098 Freiburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 418 100,33
Administrative Contact
Wolfgang Schamel (Prof.)

Participants (21)

NOVAMEN SAS

Participation ended

France
Address
Rue De La République 69
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Duvarry (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 1 156 331
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Wilkins (Mr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 581 154
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Balbino Alarcon (Prof.)
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 583 375
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gottfried Baier (Prof.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 1 164 600
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ruedi Aebersold (Dr.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 582 136
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
Administrative Contact
Ina Krischek (Dr.)
TURUN YLIOPISTO
Finland
EU contribution
€ 1 280 606
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eliisa Särkilahti (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 711 479
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Béatrice Saint-Cricq (Ms.)
UNIVERSITATSSPITAL BASEL
Switzerland
EU contribution
€ 514 000
Address
Hebelstrasse 32
4031 Basel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Ed Palmer (Prof.)
OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG
Germany
EU contribution
€ 544 040
Address
Universitaetsplatz 2
39106 Magdeburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingrid Anders (Ms.)
FONDAZIONE HUMANITAS PER LA RICERCA
Italy
EU contribution
€ 546 000
Address
Via Manzoni
20089 Rozzano
Activity type
Research Organisations
Administrative Contact
Danilo Petroni (Dr.)
MEDICEL OY

Participation ended

Finland
EU contribution
€ 373 355,86
Address
Haartmaninkatu 8
00290 Helsinki
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Risto Renkonen (Prof.)
EXBIO PRAHA AS
Czechia
EU contribution
€ 665 500
Address
Nad Safinou Ii 341
25242 Vestec
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jolana Vosáhlová (Dr.)
ACIES SAS

Participation ended

France
EU contribution
€ 53 969,89
Address
69 Rue De La République
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Duvarry (Mr.)
Immune Disease Institute
United States
Address
Huntington Avenue 800
MA 02115 Boston
Activity type
Research Organisations
Administrative Contact
Stephen Carriuolo (Mr.)
INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY
Italy
Address
Padriciano 99
34149 Trieste
Activity type
Research Organisations
Administrative Contact
H.S. Narayanan (Ms.)
Joslin Diabetes Center
United States
Address
One Joslin Place
Boston, Massachusetts
Activity type
Other
Administrative Contact
Natalie Liang (Ms.)
ACIES Consulting Group SAS
France
EU contribution
€ 306 797,11
Address
Rue De La République 69
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Duvarry (Mr.)
TTY-SAATIO
Finland
EU contribution
€ 326 644,14
Address
Korkeakoulunkatu 10
33720 Tampere
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Merja Fagerström (Ms.)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
Administrative Contact
Pastora Martinez Samper (Ms.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Participation ended

Germany
EU contribution
€ 1 291 911,67
Address
Hofgartenstrasse 8
80539 Munich
Activity type
Other
Administrative Contact
Miriam Vitt (Ms.)