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European Study to Establish Biomarkers of Human Ageing

Objective

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,300 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (“GEHA offspring”) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the study. A wide range of candidate biomarkers will be tested, including (a) “classical” ones for which data from several smaller studies have been published; (b) “new” ones, based on recent preliminary data, as well as (c) “novel” ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing.

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITAT KONSTANZ
Address
Universitatsstrasse 10
78464 Konstanz
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 450 417
Administrative Contact
Gertraud Plaza-Pascual (Ms.)

Participants (27)

BIOTESYS GMBH
Germany
EU contribution
€ 456 000
Address
Schelztorstrasse 54-56
73728 Esslingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christiane Schoen (Ms.)
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain
EU contribution
€ 498 000
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Activity type
Research Organisations
Administrative Contact
Jose Louis Narro (Mr.)
DNAGE BV

Participation ended

Netherlands
EU contribution
€ 173 051
Address
Darwinweg 24
2333CR Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ingrid Van Der Pluijm (Dr.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 500 000
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
M.A.J. Van Zeijl (Ms.)
UNIVERSITE DE NAMUR ASBL
Belgium
EU contribution
€ 454 470
Address
Rue De Bruxelles 61
5000 Namur
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michele Fontaine (Dr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Participation ended

United Kingdom
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Robinson (Mr.)
OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN
Austria
EU contribution
€ 591 309
Address
Dr. Ignaz Seipel-platz 2
1010 Wien
Activity type
Research Organisations
Administrative Contact
Beatrix Grubeck-Loebenstein (Prof.)
ISTITUTO NAZIONALE DI RIPOSO E CURA PER ANZIANI INRCA
Italy
EU contribution
€ 298 000
Address
Via Santa Margherita 5
60124 Ancona
Activity type
Research Organisations
Administrative Contact
Fiorella Marcellini (Dr.)
NESTEC SA
Switzerland
Address
Avenue Nestle 55
1800 Vevey
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sebastiano Collino (Dr.)
ETHNIKO IDRYMA EREVNON
Greece
EU contribution
€ 359 000
Address
Vas Konstantinou 48
11635 Athina
Activity type
Research Organisations
Administrative Contact
Efstathios S. Gonos (Dr.)
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 399 500
Address
Ul. Ludwika Pasteura 3
02 093 Warszawa
Activity type
Research Organisations
Administrative Contact
Marta Rucinska (Ms.)
ANA ASLAN INSTITUTE OF GERONTOLOGY AND GERIATRICS
Romania
EU contribution
€ 234 000
Address
Strada Manastirea Caldarusani 9
11241 Bucharest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniela Gradinaru (Prof.)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 682 200
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
Administrative Contact
Peter Van Altena (Mr.)
STRATICELL SCREENING TECHNOLOGIES SA
Belgium
EU contribution
€ 509 280
Address
Rue Jean Sonet 10 Parc Scientifique Crealys Cri Andromede
5032 Gembloux Les Isnes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michel Salmon (Dr.)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 358 000
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Helle Alstrup (Ms.)
ASTON UNIVERSITY
United Kingdom
EU contribution
€ 500 000
Address
Aston Triangle
B4 7ET Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gareth Evans (Mr.)
VIB VZW
Belgium
EU contribution
€ 496 500
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Dr.)
UNIVERSITAET HOHENHEIM
Germany
EU contribution
€ 959 600
Address
Schloss Hohenheim
70599 Stuttgart
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hans-Peter Liebig (Prof.)
MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG
Germany
EU contribution
€ 416 000
Address
Universitaetsplatz 10
6108 Halle (Saale)
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Manfred Jank (Dr.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 606 000
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrea Previti (Dr.)
UNILEVER U.K. CENTRAL RESOURCES LIMITED
United Kingdom
EU contribution
€ 43 000
Address
Unilever House, Victoria Embankment 100
EC4Y 0DY London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jonathan Richard Powell (Dr.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 463 000
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maurizio Palucci (Prof.)
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
France
EU contribution
€ 408 000
Address
Place Jussieu 4
75252 Paris
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bertrand Friguet (Prof.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 422 000
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karin Wibier (Ms.)
TAMPEREEN YLIOPISTO
Finland
EU contribution
€ 234 000
Address
Kalevantie 4
33014 Tampere
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hannele Auffermann (Ms.)
CRANFIELD UNIVERSITY
United Kingdom
EU contribution
€ 478 000
Address
College Road
MK43 0AL Cranfield - Bedfordshire
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rose Suzanne (Ms.)
UNIVERSITAET INNSBRUCK
Austria
Address
Innrain 52
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beatrix Grubeck-Loebenstein (Prof.)