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European Study to Establish Biomarkers of Human Ageing

Objective

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,300 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (“GEHA offspring”) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the study. A wide range of candidate biomarkers will be tested, including (a) “classical” ones for which data from several smaller studies have been published; (b) “new” ones, based on recent preliminary data, as well as (c) “novel” ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing.
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Coordinator

UNIVERSITAT KONSTANZ

Address

Universitatsstrasse 10
78464 Konstanz

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 450 417

Administrative Contact

Gertraud Plaza-Pascual (Ms.)

Participants (27)

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BIOTESYS GMBH

Germany

EU Contribution

€ 456 000

FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

Spain

EU Contribution

€ 498 000

DNAGE BV

Netherlands

EU Contribution

€ 173 051

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 500 000

UNIVERSITE DE NAMUR ASBL

Belgium

EU Contribution

€ 454 470

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN

Austria

EU Contribution

€ 591 309

ISTITUTO NAZIONALE DI RIPOSO E CURA PER ANZIANI INRCA

Italy

EU Contribution

€ 298 000

NESTEC SA

Switzerland

ETHNIKO IDRYMA EREVNON

Greece

EU Contribution

€ 359 000

INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK

Poland

EU Contribution

€ 399 500

ANA ASLAN INSTITUTE OF GERONTOLOGY AND GERIATRICS

Romania

EU Contribution

€ 234 000

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU

Netherlands

EU Contribution

€ 682 200

STRATICELL SCREENING TECHNOLOGIES

Belgium

EU Contribution

€ 509 280

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 358 000

ASTON UNIVERSITY

United Kingdom

EU Contribution

€ 500 000

VIB

Belgium

EU Contribution

€ 496 500

UNIVERSITAET HOHENHEIM

Germany

EU Contribution

€ 959 600

MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG

Germany

EU Contribution

€ 416 000

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italy

EU Contribution

€ 606 000

UNILEVER U.K. CENTRAL RESOURCES LIMITED

United Kingdom

EU Contribution

€ 43 000

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Italy

EU Contribution

€ 463 000

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

France

EU Contribution

€ 408 000

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 422 000

TAMPEREEN YLIOPISTO

Finland

EU Contribution

€ 234 000

CRANFIELD UNIVERSITY

United Kingdom

EU Contribution

€ 478 000

UNIVERSITAET INNSBRUCK

Austria

Project information

Grant agreement ID: 200880

Status

Closed project

  • Start date

    1 April 2008

  • End date

    30 September 2013

Funded under:

FP7-HEALTH

  • Overall budget:

    € 15 907 409,60

  • EU contribution

    € 11 989 327

Coordinated by:

UNIVERSITAT KONSTANZ

Germany