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Identification of Mechanisms Correlating with Susceptibility for Avian Influenza

Objective

IMECS is a proposal of the FLUSECURE network aimed at combating the threat of new and re-emerging forms of highly pathogenic influenza in its first stages of a disease by identifying mechanisms of protection that are essential for a solid immune response to avian influenza. IMECS is uniquely featured by correlating research in humans directly to protection from influenza. The IMECS initiative was introduced since the recent H5N1 avian influenza vaccine trials results have shown limited success in inducing a protective immune response as compared to the standard human influenza vaccines. This despite large investments and multiple vaccine formulations tested. These results make clear that the mechanisms of immunity for avian influenza are inherently different from those for human/seasonal influenza. The IMECS initiative aims to elucidate these mechanisms and aims to provide essential knowledge for development of breakthrough pandemic vaccines as a result. The initiative thereto boosts the development of AI-correlates of protection for the clinical screening of vaccine candidates in healthy adults and in different target groups, the origin of subclinical AI infection in humans, as well as a research programme for the screening of vaccine candidates in vitro. The following research objectives are pursued: - Determining the basis of the homologous and non-homologous mechanisms of protection for avian influenza; - Determine the mechanisms of protection in specific target groups, including infants and the elderly; - Determining the AI-specific response after vaccination in clinical trial studies. IMECS combines the knowledge of leading European universities and research centres. The multidisciplinary consortium has the resources, skills and knowledge to realize the objectives of this collaborative research project.The consortium consists of 6 partners and two subcontractors from five different European countries and one disease endemic country (SICA)

Call for proposal

FP7-HEALTH-2007-A
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Coordinator

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Netherlands

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Activity type
Research Organisations
Administrative Contact
Marjon Hartwigsen (Ms.)
EU contribution
€ 365 226

Participants (7)

VIEN VE SINH DICH TE TRUNG UONG
Vietnam
EU contribution
€ 150 584
Address
Yersin Street Hai Ba Trung 1
1000 Hanoi

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Duc Anh Dang (Prof.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finland
EU contribution
€ 492 975
Address
Mannerheimintie 166
00271 Helsinki

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Activity type
Research Organisations
Administrative Contact
Jaakko Penttinen (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 399 750
Address
Albinusdreef 2
2333 ZA Leiden

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sonja Croes (Ms.)
FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA
Switzerland
EU contribution
€ 388 379
Address
Via Francesco Chiesa 5
6500 Bellinzona

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Activity type
Research Organisations
Administrative Contact
Fosca Bognuda (Ms.)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 240 845
Address
Viale Regina Elena 299
00161 Roma

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Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Dr.)
FONDAZIONE ANDREA CESALPINO*
Italy
EU contribution
€ 111 030
Address
Via Sicilia 169
00187 Roma

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Luigino Mangiapelo (Mr.)
MINISTERIE VAN VOLKSGEZONDHEID, WELZIJN EN SPORT

Participation ended

Netherlands
EU contribution
€ 648 498
Address
Parnassusplein 5
2500 EJ Den Haag

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Ernst Soethout (Mr.)