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Investigation of the molecular pathogenesis and pathophysiology of Disorders of Sex Development (DSD)

Investigation of the molecular pathogenesis and pathophysiology of Disorders of Sex Development (DSD)

Objective

Disorders of Sex Development (DSD) constitute a group of rare to very rare mostly heritable disorders affecting the genito-urinary tract and in most instances also the endocrine-reproductive system. We hypothesize that stringent and stepwise analysis of cases with DSD will result in a systematic and reliable discovery of DSD-relevant biochemical, genetic and functional profiles, allowing for the detection of new diagnostic markers, both in steroid biosynthesis as well as in genetics to provide the basis for explaining the nature of these disorders. Characterization of the functional aspects of androgen action as the main basis for sex-related phenotype will improve the understanding of the pathophysiology of DSD phenotypes. This will allow for better decision-making in gender assignment and therapeutic approaches to DSD as well as improve gender medicine in general.
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Coordinator

UNIVERSITAT ZU LUBECK

Address

Ratzeburger Allee 160
23562 Lubeck

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 592 838

Administrative Contact

Christina Catana (Ms.)

Participants (13)

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UNIVERSITY OF GLASGOW

United Kingdom

EU Contribution

€ 250 392

INSTITUT PASTEUR

France

EU Contribution

€ 292 865

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 347 718

THE UNIVERSITY OF BIRMINGHAM

United Kingdom

EU Contribution

€ 188 232

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 188 546

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 72 200

UNIVERSITA DI PISA

Italy

EU Contribution

€ 17 000

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 26 400

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

EU Contribution

€ 231 200

HOSPICES CIVILS DE LYON

France

EU Contribution

€ 26 400

GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Germany

EU Contribution

€ 257 999

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

Germany

EU Contribution

€ 476 408

UNIVERSITEIT GENT

Belgium

EU Contribution

€ 21 000

Project information

Grant agreement ID: 201444

Status

Closed project

  • Start date

    1 May 2008

  • End date

    31 October 2011

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 894 132,34

  • EU contribution

    € 2 989 198

Coordinated by:

UNIVERSITAT ZU LUBECK

Germany