Skip to main content

Targeting OBesity-driven Inflammation

Objective

The TOBI project aims to analyse mechanisms provoking adipokine-mediated crosstalk and an inflammatory drift in obese patients. It will be the remit of this project to develop novel strategies to reduce or reverse major adipokine-mediated adverse interactions in peripheral tissues and by periorganic adipose tissue, namely insulin resistance and vascular dysfunction, respectively. Special attention will be given to the study of novel lipid-derived adipokines and the identification of targets for drug development that could interfere with the obesity-associated inflammatory drift. TOBI research focuses on molecular mechanisms initiating and promoting inflammatory signalling pathways in adipocytes and adipose tissue macrophages that cause a shift to inflammatory adipokines to interfere with insulin sensitivity and vascular function. Adipocyte dysfunction by alterations in ER stress signalling and lipolysis will be analysed as probable starting points of adipocyte inflammatory alterations. Signalling pathways and transcription factors controlling expression of inflammatory adipokines and anti-inflammatory adipokines will be studied. TOBI will particularly investigate lipid-derived adipokines that have been little studied to date. Key molecules of pathophysiological relevance will be validated for their potential as targets for drug development. The TOBI consortium will mount a comprehensive collaborative program for analysing the molecular mechanisms underlying regulation of adipokine production and their function in target tissues using genetic, molecular and biochemical approaches. The consortium combines all necessary expertise to investigate the basis of the obesity-associated inflammatory drift. A TOBI toolbox will be developed that strengthen collaboration and comparability of results. In addition the consortium includes relevant partners to exploit the results by translating them into new treatment strategies for obesity-associated adipokine-mediated disorders.

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

MEDIZINISCHE UNIVERSITAET WIEN
Address
Spitalgasse 23
1090 Wien
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 618 629
Administrative Contact
Josef Smolen (Prof.)

Participants (9)

BIOLUTION GMBH
Austria
EU contribution
€ 283 752
Address
Helmut Qualtinger Gasse 2/2
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Iris Grünert (Dr.)
UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 316 080
Address
Albertus Magnus Platz
50931 Koeln
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jutta Lanedvogt
UNIVERSITA POLITECNICA DELLE MARCHE
Italy
EU contribution
€ 187 200
Address
Piazza Roma 22
60121 Ancona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Saverio Cinti (Dr.)
GENFIT
France
EU contribution
€ 366 480
Address
885 Avenue Eugene Avinee Parc Eurosante
59120 Loos
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Matthieu Dubruque (Mr.)
PHARM-ANALYT LABOR GMBH
Austria
EU contribution
€ 112 575
Address
Ferdinand Pichlergasse 2
2500 Baden Bei Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Daniel Mascher (Dr.)
UNIVERSITY OF DURHAM
United Kingdom
EU contribution
€ 313 692
Address
Stockton Road The Palatine Centre
DH1 3LE Durham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wendy Harle (Ms.)
INSTITUT PASTEUR DE LILLE FONDATION
France
EU contribution
€ 239 400
Address
Rue Du Professeur Calmette 1
59019 Lille
Activity type
Research Organisations
Administrative Contact
Fabienne Jean (Ms.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 339 156
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
UNIVERSITAET GRAZ
Austria
EU contribution
€ 204 000
Address
Universitatsplatz 3
8010 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rudolf Zechner (Prof.)