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Molecular and cellular investigation of neuron-astroglia interactions: Understanding brain function and dysfunction

Molecular and cellular investigation of neuron-astroglia interactions: Understanding brain function and dysfunction

Objective

Astroglial cells are now recognized as active elements in the brain that sense and integrate synaptic signals and, by releasing gliotransmitters, regulate synaptic efficacy and cerebral blood flow. Despite accrued knowledge, many fundamental aspects of neuron-astroglia partnerships remain open, or have been poorly addressed in a functional context in vivo. For example, does astroglia heterogeneity reflect distinct functions? How do astroglial and neuronal networks interact locally and temporally? How does disruption of neuron-glia interactions contribute to brain disorders? Leading European research groups in the field have gathered in NeuroGLIA to address such questions using a multi-disciplinary approach, including transgenic astroglia-subtype specific mice, electrophysiology and high resolution laser scanning microscopy in vitro and in vivo (including awake mice). This will enable the consortium: i) to verify the potential of activated astroglia to signal back to neurons rapidly; ii) to define the spatial-temporal dynamics of neuron–astroglia reciprocal signalling; iii) to clarify the specific function of different astroglial subtypes in modulation of neuronal excitability and transmission, and in the control of neurovascular coupling. NeuroGLIA will also investigate how dysfunction of neuron-astroglia signalling contributes to the pathogenesis of brain disorders, focussing on epilepsy. In animal models of epilepsy, astroglial activity will be analyzed with respect to initiation, maintenance and cessation of epileptiform activity, also in relation to blood flow changes and activation of inflammatory pathways. Importantly, access to living tissue from epilepsy patients, allows NeuroGLIA to investigate neuron-astroglia interactions and its dysregulation in the human brain. NeuroGLIA is thus in the privileged position to unravel fundamental mechanisms of neuron-astroglia signalling in health and disease, opening new perspectives for specific therapeutic strategies.
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Coordinator

UNIVERSITAETSKLINIKUM BONN

Address

Sigmund-Freud-Strasse 25
53127 Bonn

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 493 404

Administrative Contact

Christian Steinhäuser (Prof.)

Participants (7)

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AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 497 580

CARDIFF UNIVERSITY

United Kingdom

EU Contribution

€ 410 820

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 451 384

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 410 184

Academisch Medisch Centrum bij de Universiteit van Amsterdam

Netherlands

EU Contribution

€ 438 300

EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH

Germany

EU Contribution

€ 190 300

UNIVERSITAT DES SAARLANDES

Germany

EU Contribution

€ 96 478

Project information

Grant agreement ID: 202167

Status

Closed project

  • Start date

    1 January 2008

  • End date

    30 June 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 917 986,40

  • EU contribution

    € 2 988 450

Coordinated by:

UNIVERSITAETSKLINIKUM BONN

Germany