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European IPF Network: Natural course, Pathomechanisms and Novel Treatment Options in Idiopathic Pulmonary Fibrosis

Obiettivo

In the eurIPFnet consortium, leading European basic and clinical scientists in the field of interstitial lung diseases associate to jointly decipher the natural course and molecular pathomechanisms of Idiopathic Pulmonary Fibrosis (IPF) and to develop new therapeutic strategies for patients with IPF. This devastating disease affects about 360.000 patients in the EU and causes a substantial socioeconomic burden. IPF patients experience a gradual decrease in quality of life due to progressive dyspnoe and coughing, and usually die within 3-5 years upon diagnosis. There is currently no approved treatment available. Our translational research programme includes implementation of a European IPF registry (eurIPFreg), in which data with regard to natural course, familiar background and susceptibility factors of IPF will be collected, and of a European IPF biobank (eurIPFbank) of blood, bronchoalveolar lavage fluid, cells and tissue specimen of IPF. In these samples, we will perform transcriptome, proteome, phosphoproteome and lipidome analysis, cellular studies and genetic analysis to unravel the molecular pathways underlying IPF and to identify and establish new diagnostic and prognostic markers. Candidate gene verification will be performed in cell culture and animal studies, including siRNA and gene transfection technologies and development of genetically altered mice and will result in the development of new animal models of IPF. Identification of new therapeutic targets in these models will be followed by rapid commercial exploitation and early preclinical and early clinical evaluation. Ultimately, we wish to establish a unique, sustainable and internationally unrivalled European infrastructure for investigation and treatment of IPF. Our mission statement is straight-forward and clear: “Fighting for improved survival in Idiopathic Pulmonary Fibrosis”.

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Coordinatore

JUSTUS-LIEBIG-UNIVERSITAET GIESSEN
Indirizzo
Ludwigstrasse 23
35390 Giessen
Germania

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Sandy Jones (Ms.)
Contributo UE
€ 1 189 546,50

Partecipanti (11)

UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
Contributo UE
€ 322 880
Indirizzo
Gower Street
WC1E 6BT London

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Kent Lee (Mr.)
ROYAL BROMPTON AND HAREFIELD NATIONAL HEALTH SERVICE TRUST
United Kingdom
Contributo UE
€ 160 620
Indirizzo
Sydney Street
SW3 6NP London

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
George Karagiannis (Prof.)
UNIVERSITA DEGLI STUDI DI CATANIA
Italia
Contributo UE
€ 232 336
Indirizzo
Piazza Universita 2
95131 Catania

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Sebastiano Squatrito (Prof.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Francia
Contributo UE
€ 480 218
Indirizzo
Rue De Tolbiac 101
75654 Paris

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Tipo di attività
Research Organisations
Contatto amministrativo
Dina Ramamonjisoa (Ms.)
KLINIKUM DER UNIVERSITAET REGENSBURG
Germania
Contributo UE
€ 59 700
Indirizzo
Frans Josef Strauss Allee 11
93053 Regensburg

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Jean Fugate (Ms.)
JERINI AG

Partecipazione conclusa

Germania
Contributo UE
€ 137 398,50
Indirizzo
Invalidenstrasse 130
10115 Berlin

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Gerd Hummel (Dr.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Contributo UE
€ 68 700
Indirizzo
Spitalgasse 23
1090 Wien

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Ferdinand Muehlbacher (Prof.)
KLINIKUM DER UNIVERSITAET ZU KOELN

Partecipazione conclusa

Germania
Indirizzo
Kerpener Strasse 62
50937 Koeln

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Jutta Landvogt (Ms.)
TransMIT Gesellschaft fuer Technologietransfer mbH
Germania
Contributo UE
€ 20 250
Indirizzo
Kerkrader Strasse 3
35394 Giessen

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Michael Haberland (Mr.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germania
Contributo UE
€ 170 640
Indirizzo
Ingolstadter Landstrasse 1
85764 Neuherberg

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Tipo di attività
Research Organisations
Contatto amministrativo
Juergen Ertel (Dr.)
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germania
Contributo UE
€ 156 300
Indirizzo
Regina Pacis Weg 3
53113 Bonn

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Daniela Hasenpusch (Ms.)