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Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease

Objective

Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quantification of alterations of the total lipid profile after specific perturbations. In combination with advanced proteome and transcriptome analysis tools and novel imaging techniques using RNA interference, it is now possible to unravel the complex network between lipids, genes and proteins in an integrated lipidomics approach. This project application of the European Lipidomics Initiative (ELife; www.lipidomics.net) will address lipid droplets (LD) as dynamic organelles with regard to composition, metabolism and regulation. LD are the hallmark of energy overload diseases with a major health care impact in Europe. The project will exploit recent advances in lipidomics to establish high-throughput methods to define drugable targets and novel biomarkers related to LD lipid and protein species, their interaction and regulation during assembly, disassembly and storage. Translational research from mouse to man applied to LD pathology is a cornerstone of this project at the interface between research and development. To maximize the value of the assembled data generated throughout the project, “LipidomicNet” as a detailed special purpose Wiki formate data base will be developed and integrated into the existing Lipidomics Expertise Platform (LEP) established through the SSA ELife project (www.lipidomics-expertise.de). ELife collaborates with the NIH initiative LIPID MAPS (www.lipidmaps.org) and the Japanese pendant Lipidbank (www.lipidbank.jp) and is connected to the Danubian Biobank consortium (SSA DanuBiobank, www.danubianbiobank.de) for clinical lipidomics.

Call for proposal

FP7-HEALTH-2007-A
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Coordinator

KLINIKUM DER UNIVERSITAET REGENSBURG
Address
Frans Josef Strauss Allee 11
93053 Regensburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 080 566
Administrative Contact
Gerd Schmitz (Prof.)

Participants (26)

UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 677 400
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Monique Hoek, Van Der (Mr.)
CONSORZIO MARIO NEGRI SUD.
Italy
EU contribution
€ 250 000
Address
Via Nazionale 8/A
66030 Santa Maria Imbaro
Activity type
Research Organisations
Administrative Contact
Claude Alain Di Menno (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 343 162
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Mihaja Auguste (Ms.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 235 800
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daan Katchaki (Dr.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 313 600
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Wolfrum (Dr.)
UNIVERSITAET GRAZ
Austria
EU contribution
€ 487 320
Address
Universitatsplatz 3
8010 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Friedrich Spener (Prof.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 341 582
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margareta Ahlqwist (Dr.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Participation ended

Germany
EU contribution
€ 187 167,67
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
Administrative Contact
Birgit Knepper (Dr.)
SZEGEDI BIOLOGIAI KUTATOKOZPONT
Hungary
EU contribution
€ 130 000
Address
Temesvari Korut 62
6726 Szeged
Activity type
Research Organisations
Administrative Contact
Janos Bathori (Dr.)
USTAV EXPERIMENTALNEJ ENDOKRINOLOGIE - SLOVENSKEJ AKADEMIE VIED
Slovakia
EU contribution
€ 252 900
Address
Vlarska 3
83306 Bratislava
Activity type
Research Organisations
Administrative Contact
Magdalena Grackova (Ms.)
THE BABRAHAM INSTITUTE
United Kingdom
EU contribution
€ 413 727
Address
Babraham Hall
CB22 3AT Cambridge
Activity type
Research Organisations
Administrative Contact
Fang Gao (Ms.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 537 600
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Berg (Ms.)
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany
EU contribution
€ 717 192,33
Address
Regina Pacis Weg 3
53113 Bonn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniela Hasenpusch (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 436 000
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Keith Williamson (Mr.)
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
EU contribution
€ 237 000
Address
Robert-koch-strasse 40
37075 Goettingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christiane Hennecke (Ms.)
BIOBASE GMBH
Germany
EU contribution
€ 229 700
Address
Halchtersche Strasse 33
38304 Wolfenbuettel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Tysiak (Mr.)
ZORA BIOSCIENCES OY
Finland
EU contribution
€ 300 000
Address
Tietotie 2 C
02150 Espoo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Reini Hurme (Dr.)
PROTAGEN AG
Germany
EU contribution
€ 542 400
Address
Otto-hahn-strasse 15
44227 Dortmund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sven Rüger (Mr.)
INTEGROMICS SL ITG
Spain
EU contribution
€ 305 140
Address
Avenida De Innovacion 1 Bic Granada Parque Tecnologia Ciencas De La Salud
18100 Armilla -Granada
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marco Rodriguez Junker (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 304 535
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Edward Gibbs (Mr.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 268 538
Address
North Star Avenue Polaris House
SN2 1FL Swindon
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Agnes Simpson (Ms.)
UNIVERSITAT LINZ

Participation ended

Austria
EU contribution
€ 67 694,83
Address
Altenberger Strasse 69
4040 Linz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerhard J Schütz (Prof.)
INSTITUTE OF SYSTEMS BIOLOGY LTD
Russia
EU contribution
€ 214 000
Address
Krasina Street 54, Office 901
630112 Novosibirsk
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sergey Zhatchenko (Mr.)
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
EU contribution
€ 105 000
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingo Niendorf (Mr.)
UNIWERSYTET JAGIELLONSKI
Poland
EU contribution
€ 563 600
Address
Ul. Golebia 24
31007 Krakow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katarzyna Gubernat (Ms.)
TECHNISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 62 305,17
Address
Karlsplatz 13
1040 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerhard J. Schuetz (Dr.)