CORDIS
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CORDIS

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Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease

Project information

Grant agreement ID: 202272

Status

Closed project

  • Start date

    1 May 2008

  • End date

    31 October 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 16 022 988,28

  • EU contribution

    € 11 603 930

Coordinated by:

KLINIKUM DER UNIVERSITAET REGENSBURG

Germany

Objective

Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quantification of alterations of the total lipid profile after specific perturbations. In combination with advanced proteome and transcriptome analysis tools and novel imaging techniques using RNA interference, it is now possible to unravel the complex network between lipids, genes and proteins in an integrated lipidomics approach. This project application of the European Lipidomics Initiative (ELife; www.lipidomics.net) will address lipid droplets (LD) as dynamic organelles with regard to composition, metabolism and regulation. LD are the hallmark of energy overload diseases with a major health care impact in Europe. The project will exploit recent advances in lipidomics to establish high-throughput methods to define drugable targets and novel biomarkers related to LD lipid and protein species, their interaction and regulation during assembly, disassembly and storage. Translational research from mouse to man applied to LD pathology is a cornerstone of this project at the interface between research and development. To maximize the value of the assembled data generated throughout the project, “LipidomicNet” as a detailed special purpose Wiki formate data base will be developed and integrated into the existing Lipidomics Expertise Platform (LEP) established through the SSA ELife project (www.lipidomics-expertise.de). ELife collaborates with the NIH initiative LIPID MAPS (www.lipidmaps.org) and the Japanese pendant Lipidbank (www.lipidbank.jp) and is connected to the Danubian Biobank consortium (SSA DanuBiobank, www.danubianbiobank.de) for clinical lipidomics.
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Coordinator

KLINIKUM DER UNIVERSITAET REGENSBURG

Address

Frans Josef Strauss Allee 11
93053 Regensburg

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 3 080 566

Administrative Contact

Gerd Schmitz (Prof.)

Participants (26)

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 677 400

FONDAZIONE MARIO NEGRI SUD-CENTRO DI RICERCHE FARMACOLOGICHE EB IOMEDICHE

Italy

EU Contribution

€ 250 000

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 343 162

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 235 800

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 313 600

UNIVERSITAET GRAZ

Austria

EU Contribution

€ 487 320

GOETEBORGS UNIVERSITET

Sweden

EU Contribution

€ 341 582

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 187 167,67

SZEGEDI BIOLOGIAI KUTATOKOZPONT

Hungary

EU Contribution

€ 130 000

USTAV EXPERIMENTALNEJ ENDOKRINOLOGIE - SLOVENSKEJ AKADEMIE VIED

Slovakia

EU Contribution

€ 252 900

THE BABRAHAM INSTITUTE

United Kingdom

EU Contribution

€ 413 727

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 537 600

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN

Germany

EU Contribution

€ 717 192,33

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 436 000

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS

Germany

EU Contribution

€ 237 000

BIOBASE GMBH

Germany

EU Contribution

€ 229 700

ZORA BIOSCIENCES OY

Finland

EU Contribution

€ 300 000

PROTAGEN AG

Germany

EU Contribution

€ 542 400

INTEGROMICS SL ITG

Spain

EU Contribution

€ 305 140

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 304 535

MEDICAL RESEARCH COUNCIL

United Kingdom

EU Contribution

€ 268 538

UNIVERSITAT LINZ

Austria

EU Contribution

€ 67 694,83

INSTITUTE OF SYSTEMS BIOLOGY LTD

Russia

EU Contribution

€ 214 000

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

EU Contribution

€ 105 000

UNIWERSYTET JAGIELLONSKI

Poland

EU Contribution

€ 563 600

TECHNISCHE UNIVERSITAET WIEN

Austria

EU Contribution

€ 62 305,17

Project information

Grant agreement ID: 202272

Status

Closed project

  • Start date

    1 May 2008

  • End date

    31 October 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 16 022 988,28

  • EU contribution

    € 11 603 930

Coordinated by:

KLINIKUM DER UNIVERSITAET REGENSBURG

Germany

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