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Time-resolved diffusive X-ray scattering for the study of cell membrane transport

Time-resolved diffusive X-ray scattering for the study of cell membrane transport

Objective

In this application we propose to apply the emerging tools of solution-phase, time-resolved X-ray scattering to the study of transfer phenomena in membrane transport proteins. Diffusive X-ray scattering of heavy metals in solution has recently been used by the host to monitor reaction kinetics of simple photochemical systems on a picosecond timescale. We seek to extend the technique to monitor structural dynamics inside the transport channel of halorhodopsin (hR), an important membrane protein that transports halides after photoactivation. The proposed experiment on hR will yield a movie of ion transport in the channel with the aim to clarify into the mechanism of trans-membrane ion transport. Success in the project will open new experimental windows for the study of basic cellular processes of tremendous scientific and biomedical importance.
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Coordinator

GOETEBORGS UNIVERSITET

Address

Vasaparken
405 30 Goeteborg

Sweden

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 177 320,91

Administrative Contact

Ludde Edgren (Dr.)

Project information

Grant agreement ID: 220048

Status

Closed project

  • Start date

    1 May 2008

  • End date

    31 August 2010

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 177 320,91

  • EU contribution

    € 177 320,91

Coordinated by:

GOETEBORGS UNIVERSITET

Sweden