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Targeted DISCOvery of novel cellulases and hemicellulases and their reaction mechanisms for hydrolysis of lignocellulosic biomass

Objective

The aim of the proposed DISCO project is to develop more efficient and therefore more cost-effective cellulosic and hemicellulosic enzyme tools for the enhanced hydrolysis of pre-treated lignocellulosic biomass in simultaneous saccharification and fermentation (SSF) conditions for bioethanol production. The focus will be on enzymes having increased catalytic activity on various types of relevant European lignocellulosic biomass. In addition enzymes with lower affinity for lignin shall also be developed. Such enzymes would increase the effective amount of cellulases/ hemicellulases for cellulose hydrolysis. Furthermore the recycling of these enzymes would be applicable. The approach in this proposal is to discover the desired activities by combining classical and modern screening technologies. The enzymes will be produced in suitable host systems for industrial enzyme production. The project also focuses on elucidation of enzymatic hydrolysis mechanisms, about which there is a paucity of knowledge. The project will determine the limiting structural factors in these mechanisms by characterisation of the substrate during the course of the hydrolysis and the remaining recalcitrant residue. Synergy between different cellulase and hemicellulases components will also be addresses on the chosen lignocellulosic substrates. Furthermore, the project seeks to demonstrate the proof of concept with the cellulolytic enzymes in a pilot scale using the most relevant European feedstock pretreated wheat straw and related high-volume co-products.

Coordinator

TEKNOLOGIAN TUTKIMUSKESKUS VTT

Address

Tekniikantie 4 A
02044 Vtt Espoo

Finland

Activity type

Research Organisations

EU Contribution

€ 800 000

Administrative Contact

Riitta Kervinen (Ms.)

Participants (11)

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COOPERATIE CEHAVE LANDBOUWBELANG U.A.

Netherlands

EU Contribution

€ 21 500

WAGENINGEN UNIVERSITY

Netherlands

EU Contribution

€ 395 505

QUADRAM INSTITUTE BIOSCIENCE

United Kingdom

EU Contribution

€ 395 000

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 413 400

A.N. BAKH INSTITUTE OF BIOCHEMISTRY OF THE RUSSIAN ACADEMY OF SCIENCES

Russia

EU Contribution

€ 225 000

BUDAPESTI MUSZAKI ES GAZDASAGTUDOMANYI EGYETEM

Hungary

EU Contribution

€ 189 750

DYADIC NEDERLAND BV

Netherlands

EU Contribution

€ 328 190

BIOGOLD OU

Estonia

EU Contribution

€ 97 500

G R WRIGHT AND SONS LTD

United Kingdom

EU Contribution

€ 25 000

SEKAB E-TECHNOLOGY AB

Sweden

EU Contribution

€ 95 000

AGRIFIRM GROUP BV

Netherlands

Project information

Grant agreement ID: 211863

Status

Closed project

  • Start date

    1 August 2008

  • End date

    31 July 2012

Funded under:

FP7-KBBE

  • Overall budget:

    € 4 001 460

  • EU contribution

    € 2 985 845

Coordinated by:

TEKNOLOGIAN TUTKIMUSKESKUS VTT

Finland

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