CORDIS
EU research results

CORDIS

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Contaminant mixtures and human reproductive health - novel strategies for health impact and risk assessment of endocrine disrupters

Project information

Grant agreement ID: 212502

Status

Closed project

  • Start date

    1 May 2008

  • End date

    31 October 2012

Funded under:

FP7-ENVIRONMENT

  • Overall budget:

    € 4 584 536

  • EU contribution

    € 3 494 352

Coordinated by:

BRUNEL UNIVERSITY LONDON

United Kingdom

Objective

Disruption of hormonal signalling in fetal life can irreversibly affect human development and reproductive health at a later age. Of considerable concern in Europe is a decline in male semen quality and a high prevalence of congenital malformations and hormone-dependent cancers. Although it appears plausible that environmental chemicals with endocrine activity may be involved in the causation of these disorders, there is no evidence for adverse effects of individual substances at relevant human exposure levels. However, there are indications that combinations of chemicals play a cumulative role. CONTAMED aims to explore the hypothesis that combined exposure to endocrine disrupting chemicals in fetal life may lead to adverse delayed impacts on human reproductive health. To achieve this goal, CONTAMED will combine epidemiological approaches with laboratory science. The work plan for CONTAMED is organised in three major strands focusing on human studies, animal models and in vitro assays including metabolomics. The project will deliver new epidemiological insights into associations between cumulative exposure and reproductive health, improved toxicological risk assessment for the anticipation of reproductive effects of chemicals, validated biomarkers for cumulative exposures and new mechanistic information about the ways in which chemicals may disrupt sexual differentiation during development. CONTAMED will provide the knowledge necessary to set the scene for Europe-wide human health impact studies of cumulative exposures to endocrine active chemicals and their possible role in the deterioration of reproductive health in Europe. Finally, the project will analyze the implications of new scientific findings for the European Environment and Health Action Plan and the Community Strategy for Endocrine Disrupters.

Coordinator

BRUNEL UNIVERSITY LONDON

Address

Kingston Lane
Ub8 3ph Uxbridge

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 323 304,59

Administrative Contact

Andreas Kortenkamp (Prof.)

Participants (8)

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU Contribution

€ 603 129,20

THE UNIVERSITY OF SUSSEX

United Kingdom

EU Contribution

€ 499 990,80

UNIVERSIDAD DE GRANADA

Spain

EU Contribution

€ 399 072,80

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 323 060,40

GREEN TOX GMBH

Switzerland

EU Contribution

€ 499 814

FAUST UND BACKHAUS ENVIRONMENTAL CONSULTING GBR

Germany

EU Contribution

€ 150 000

UNIVERSITY OF BRISTOL

United Kingdom

EU Contribution

€ 290 734,80

THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON

United Kingdom

EU Contribution

€ 405 245,41

Project information

Grant agreement ID: 212502

Status

Closed project

  • Start date

    1 May 2008

  • End date

    31 October 2012

Funded under:

FP7-ENVIRONMENT

  • Overall budget:

    € 4 584 536

  • EU contribution

    € 3 494 352

Coordinated by:

BRUNEL UNIVERSITY LONDON

United Kingdom