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Contaminant mixtures and human reproductive health - novel strategies for health impact and risk assessment of endocrine disrupters

Objective

Disruption of hormonal signalling in fetal life can irreversibly affect human development and reproductive health at a later age. Of considerable concern in Europe is a decline in male semen quality and a high prevalence of congenital malformations and hormone-dependent cancers. Although it appears plausible that environmental chemicals with endocrine activity may be involved in the causation of these disorders, there is no evidence for adverse effects of individual substances at relevant human exposure levels. However, there are indications that combinations of chemicals play a cumulative role. CONTAMED aims to explore the hypothesis that combined exposure to endocrine disrupting chemicals in fetal life may lead to adverse delayed impacts on human reproductive health. To achieve this goal, CONTAMED will combine epidemiological approaches with laboratory science. The work plan for CONTAMED is organised in three major strands focusing on human studies, animal models and in vitro assays including metabolomics. The project will deliver new epidemiological insights into associations between cumulative exposure and reproductive health, improved toxicological risk assessment for the anticipation of reproductive effects of chemicals, validated biomarkers for cumulative exposures and new mechanistic information about the ways in which chemicals may disrupt sexual differentiation during development. CONTAMED will provide the knowledge necessary to set the scene for Europe-wide human health impact studies of cumulative exposures to endocrine active chemicals and their possible role in the deterioration of reproductive health in Europe. Finally, the project will analyze the implications of new scientific findings for the European Environment and Health Action Plan and the Community Strategy for Endocrine Disrupters.

Call for proposal

FP7-ENV-2007-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

BRUNEL UNIVERSITY LONDON
Address
Kingston Lane
UB8 3PH Uxbridge
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 323 304,59
Administrative Contact
Andreas Kortenkamp (Prof.)

Participants (8)

DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 603 129,20
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulla Hass (Dr.)
THE UNIVERSITY OF SUSSEX
United Kingdom
EU contribution
€ 499 990,80
Address
Sussex House Falmer
BN1 9RH Brighton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elizabeth Hill (Dr.)
UNIVERSIDAD DE GRANADA
Spain
EU contribution
€ 399 072,80
Address
Cuesta Del Hospicio Sn
18071 Granada
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nicolas Olea Serrano (Prof.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 323 060,40
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alex Burdorf (Dr.)
GREEN TOX GMBH
Switzerland
EU contribution
€ 499 814
Address
Langackerstrasse 49
8057 Zurich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Walter Lichtensteiger (Prof.)
FAUST UND BACKHAUS ENVIRONMENTAL CONSULTING GBR
Germany
EU contribution
€ 150 000
Address
Fahrenheitstrasse 1
28359 Bremen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Faust (Dr.)
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 290 734,80
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vince Boyle (Mr.)
THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON

Participation ended

United Kingdom
EU contribution
€ 405 245,41
Address
Brunswick Square 29-39
WC1N 1AX London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andreas Kortenkamp (Prof.)