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Restorative Plasticity At Corticostriatal Excitatory Synapses

Objective

Long-lasting, activity-dependent synaptic changes are thought to underlie the ability of the brain to translate experiences into memories and seem to represent the cellular model underlying learning and memory processes. Alteration of brain plasticity may lead to the motor and cognitive disturbances observed in neurodegenerative diseases. Therapeutic approaches targeting synaptic plasticity could prevent neuronal degeneration and restore altered motor and cognitive functions. Long-term synaptic plasticity, long-term potentiation and long-term depression, are widely expressed at excitatory synapses throughout the brain and have both been described at corticostriatal connections, at which they might underlie motor-skill learning, cognitive performance and reward mechanisms. Unique feature of corticostriatal plasticity is the observation that the loss of these opposite forms of synaptic plasticity has been observed in experimental models of neurodegenerative disorders such as Parkinson’s disease (PD). REPLACES will use cortical striatal plasticity and its alterations in experimental PD to explore basic mechanisms of brain plasticity and repair and to translate the new generated knowledge into novel restorative therapeutic approaches. The long-term efficacy of new treatments for PD will be conditioned by their ability to restore, structurally and functionally, the synaptic wiring of striatal neurons and physiological synaptic plasticity. REPLACES addresses the potential restorative effects of either novel pharmacological treatments or neuronal transplants on the corticostriatal microcircuitry. Since chronic treatment with DA precursor L-DOPA induces in the majority of PD patients a maladaptative plasticity causing dyskinesia, innovative strategies should prevent the development of this disabling condition. REPLACES will characterize corticostriatal synaptic plasticity from molecular aspects to clinical neurophysiology involving behavioural and morphological analysis.

Call for proposal

FP7-HEALTH-2007-B
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Coordinator

UNIVERSITA DEGLI STUDI DI MILANO
Address
Via Festa Del Perdono 7
20122 Milano
Italy

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Monica Di Luca (Prof.)
EU contribution
€ 619 957,49

Participants (11)

FONDAZIONE SANTA LUCIA
Italy
EU contribution
€ 498 001
Address
Via Ardeatina 306
00179 Roma

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Activity type
Research Organisations
Administrative Contact
Paolo Calabresi (Prof.)
LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE
Germany
EU contribution
€ 377 785
Address
Brenneckestrasse 6
39118 Magdeburg

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Activity type
Research Organisations
Administrative Contact
Eckart D. Gundelfinger (Prof.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 407 294
Address
Rue De Tolbiac 101
75654 Paris

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Activity type
Research Organisations
Administrative Contact
Mihaja Auguste (Ms.)
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 400 830
Address
Newport Road 30 36
CF24 0DE Cardiff

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nick Bodycombe (Mr.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 500 052
Address
Paradisgatan 5c
22100 Lund

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Nordin (Ms.)
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Spain
EU contribution
€ 344 380
Address
Avenida De Pio Xii 55
31008 Pamplona

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Activity type
Research Organisations
Administrative Contact
Andrew Solomon (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 370 146
Address
Gower Street
WC1E 6BT London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kent Lee (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 376 745
Address
Rue Michel Ange 3
75794 Paris

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Activity type
Research Organisations
Administrative Contact
Bernard Jollans (Mr.)
ASSOCIATION EUROPEENNE POUR LA MALADIE DE PARKINSON
Belgium
EU contribution
€ 80 000
Address
Avenue Besme 93
1190 Bruxelles

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Activity type
Other
Administrative Contact
Lizzie Graham (Ms.)
CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL
Italy
EU contribution
€ 160 000
Address
Via Giuseppe Mussi 1
20154 Milano

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carla Finocchiaro (Mrs.)
XIGEN SA

Participation ended

Switzerland
EU contribution
€ 84 575,51
Address
Rue Des Terraux 17
1003 Lausanne

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Géraldine Dury (Ms.)