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OLIGOPEPTIDASE INHIBITORS IN BRAIN FUNCTION AND DYSFUNCTION: TOWARDS NEW THERAPEUTIC STRATEGIES FOR NEUROPROTECTION

Objective

At present more than 5 million people in the EU suffer from dementia and other neurodegenerative diseases and that number will grow as the average age of the population continues to increase. The efficacy of current medicines is limited and new therapeutic targets are sorely needed. Several independent lines of evidence have established an important role of prolyl oligopeptidase (PREP) in brain function and dysfunction. Aberrant PREP activity is involved in the progression of neurodegenerative disorders and PREP inhibitors are being developed for the treatment of memory and cognition deficits. Now a consortium of expert scientists from 8 academic institutes and 3 SME's come together for 4 years in this NEUROPRO project to boost European research aimed at 1) unravelling the biological role of PREP and PREP-like proteins in neuropathology, 2) determining the mode of action of PREP inhibitors and 3) firmly establishing their therapeutic potential. Specialists from different disciplines – cell and molecular biology, enzymology, chemistry, crystallography, biology and pharmacology – will work in a concerted and focussed way to achieve the goals using 6 work packages concentrating on PREP-regulated pathways in health and disease, PREP substrates, inhibitor target identification, drug development and validation, and generation of specific cell lines and animal models of neurodegenerative diseases. The SME’s involved are leaders in PREP inhibitor development and peptide analysis, and have in the past already brought novel therapeutics on the market. By the end of the project we expect to have proof of concept that PREP inhibition is a valid therapeutic target which will ultimately lead to new methods for the early detection, prevention or restoration of PREP-related neurodegeneration. The project also comprises instruments to translate basic research into clinical applications and will thus broaden the scope of treatments available to Europe's ageing population.

Field of science

  • /natural sciences/biological sciences/molecular biology
  • /natural sciences/biological sciences/neurobiology

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
3000 Leuven
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 732 983
Administrative Contact
Elke Lammertyn (Dr.)

Participants (11)

MAGYAR TUDOMANYOS AKADEMIA SZEGEDI BIOLOGIAI KOZPONT ENZIMOLOGIAI INTEZET

Participation ended

Hungary
Address
Karolina Ut 29-31
1113 Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mária Wagner (Ms.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 439 144
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sanna-Maija Miettinen (Dr.)
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 433 334
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sabine Herden (Dr.)
TERMESZETTUDOMANYI KUTATOKOZPONT
Hungary
EU contribution
€ 264 589
Address
Magyar Tudosok Korutja 2
1117 Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Zoltán Szeltner (Dr.)
THE UNIVERSITY OF WARWICK
United Kingdom
EU contribution
€ 433 436
Address
Kirby Corner Road - University House
CV4 8UW Coventry
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Hedges (Dr.)
TARTU ULIKOOL
Estonia
EU contribution
€ 428 070
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alexander Zharkovsky (Prof.)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 419 342
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Ms.)
PROBIODRUG AG
Germany
EU contribution
€ 344 000
Address
Weinbergweg 22
06120 Halle
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Matthias Hoffmann (Mr.)
PEPSCAN PRESTO BV
Netherlands
EU contribution
€ 494 000
Address
Zuidersluisweg 2
8243 RC Lelystad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nard Langendijk (Mr.)
CHARLES RIVER DISCOVERY RESEARCH SERVICES FINLAND OY
Finland
EU contribution
€ 450 200
Address
Microkatu 1
70210 Kuopio
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kirsi Pohjolainen (Ms.)
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 349 122
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jaana Backman (Ms.)