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Stem Cell Expansion - Expansion and engraftment of haematopoietic and mesenchymal stem cells

Objective

Serious disorders of the blood system, particularly malignant blood disorders and genetic diseases can be effectively treated by blood and marrow transplantation. Despite considerable success with this treatment modality during the last decades, lack of suitable donors, engraftment failure and graft versus host disease remain serious problems that need to be addressed. This project aims to address these issues through approaches that will allow expansion of human umbilical cord blood stem cells for transplantation using cytokines, developmental cues, newly identified stem cell regulators and chemicals that can activate internal stem cell regulators to stimulate self-renewal and proliferation of hematopoietic stem cells. Successful expansion of cord blood stem cells will increase the number of hematopoietic stem cells in cord blood samples to generate suitable donor samples for adult patients that die from their disease today due to lack of donors. Expansion of hematopoietic stem- and progenitor cells will also give more efficient early engraftment following transplantation and thereby reduce the frequency of morbidity and mortality due to insufficient engraftment. This will be accomplished through the identification of novel stem cell regulators and the use of known cytokines, developmental cues and chemicals that will stimulate stem cell expansion. Improvement in hematopoietic stem cell transplantation through co-transplantation of mesenchymal stem cells will also be investigated. Conditions for expansion of mesenchymal stem cells will be defined and subsets of more primitive and more mature mesenchymal stem cells will be identified. Mesenchymal stem cells will also be used to improve engraftment efficiency of the expanded hematopoietic cells and to reduce the frequency of graft versus host disease. The findings are expected to have a great impact on the treatment of serious blood disorders by blood and marrow transplantation in the future.

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Coordinator

MAX IV Laboratory, Lund University
Address
Paradisgatan 5C
22100 Lund
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 942 696
Administrative Contact
Jens Forsberg (Dr.)

Participants (7)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 496 942,19
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Polik (Ms.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 406 404
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Breeuwsma (Mr.)
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
France
EU contribution
€ 272 560
Address
3 Avenue Victoria
75004 Paris
Activity type
Research Organisations
Administrative Contact
Christian Nicolas (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 406 654
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sonja Croes (Ms.)
MEDICAL RESEARCH COUNCIL

Participation ended

United Kingdom
EU contribution
€ 90 669,76
Address
North Star Avenue Polaris House
SN2 1FL Swindon
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Anne-Marie Coriat (Dr.)
KUROS BIOSCIENCES BV
Netherlands
EU contribution
€ 160 038
Address
Professor Bronkhorstlaan 10 G 48
3723 MB Bilthoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Joost De Bruijn (Prof.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 219 426,05
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)