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Set up and comparison of multiple stem cell approaches for kidney repair

Objective

With the increasing rate of end-stage renal failure and limited alternatives for its treatment, potential regenerative approaches for kidney damages are urgently needed. Because of the complexity of the organ, the development of stem cell therapies for kidney is still in its infancy. Identifying which cell types are capable of beneficial effects is the critical step required to realize the potential of this therapeutic approach. Three possible sources of stem cells can be envisioned for the development of this type of treatment: (i) bone-marrow-derived stem cells, (ii) renal adult stem cells, and (iii) fetal renal stem cells. The focus of this project is to assess the regenerative potential of stem cells derived from different sources and investigate the possible obstacles to their utilization, as well as their potential side effects in preclinical models of acute and chronic renal failure. Indeed, the clinical usefulness of the treatment, as well as the need to understand currently discrepant results, require comparative experimental studies that have never been performed before either in SC therapy of kidney injury, or in that of other organs. Hopefully, this comparison will allow to set up standardized protocols of SC isolation and administration for phase I/II trials in patients affected by acute and chronic renal failure.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITA DEGLI STUDI DI FIRENZE
Address
Piazza San Marco 4
50121 Florence
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 510 000
Administrative Contact
Enrico Maggi (Prof.)

Participants (10)

WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 390 000
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
UNIVERSITAETSKLINIKUM AACHEN
Germany
EU contribution
€ 250 800
Address
Pauwelsstrasse 30
52074 Aachen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Volker Legewie (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 246 000
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sonja Croes (Ms.)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 450 000
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Administrative Contact
Maria Grazia Pezzoni (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 342 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Cedrine Pederiva (Ms.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 210 000
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
OULUN YLIOPISTO
Finland
EU contribution
€ 210 000
Address
Pentti Kaiteran Katu 1
90014 Oulu
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Risteli Leila (Dr.)
MILTENYI BIOTEC GMBH
Germany
EU contribution
€ 180 300
Address
Friedrich Ebert Strasse 68
51429 Bergish Gladbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Apel (Dr.)
ARETA INTERNATIONAL SRL
Italy
EU contribution
€ 120 000
Address
Viale Regina Giovanna 17
20129 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Maria Luisa Nolli (Dr.)
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italy
EU contribution
€ 90 400
Address
Via Fiorentina 151
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cristiana Tozzi (Dr.)