CORDIS
EU research results

CORDIS

English EN

Set up and comparison of multiple stem cell approaches for kidney repair

Project information

Grant agreement ID: 223007

Status

Closed project

  • Start date

    1 November 2008

  • End date

    31 October 2011

Funded under:

FP7-HEALTH

  • Overall budget:

    € 4 052 900

  • EU contribution

    € 2 999 500

Coordinated by:

UNIVERSITA DEGLI STUDI DI FIRENZE

Italy

Objective

With the increasing rate of end-stage renal failure and limited alternatives for its treatment, potential regenerative approaches for kidney damages are urgently needed. Because of the complexity of the organ, the development of stem cell therapies for kidney is still in its infancy. Identifying which cell types are capable of beneficial effects is the critical step required to realize the potential of this therapeutic approach. Three possible sources of stem cells can be envisioned for the development of this type of treatment: (i) bone-marrow-derived stem cells, (ii) renal adult stem cells, and (iii) fetal renal stem cells. The focus of this project is to assess the regenerative potential of stem cells derived from different sources and investigate the possible obstacles to their utilization, as well as their potential side effects in preclinical models of acute and chronic renal failure. Indeed, the clinical usefulness of the treatment, as well as the need to understand currently discrepant results, require comparative experimental studies that have never been performed before either in SC therapy of kidney injury, or in that of other organs. Hopefully, this comparison will allow to set up standardized protocols of SC isolation and administration for phase I/II trials in patients affected by acute and chronic renal failure.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITA DEGLI STUDI DI FIRENZE

Address

Piazza San Marco 4
50121 Florence

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 510 000

Administrative Contact

Enrico Maggi (Prof.)

Participants (10)

WEIZMANN INSTITUTE OF SCIENCE

Israel

EU Contribution

€ 390 000

UNIVERSITAETSKLINIKUM AACHEN

Germany

EU Contribution

€ 250 800

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 246 000

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

Italy

EU Contribution

€ 450 000

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 342 000

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 210 000

OULUN YLIOPISTO

Finland

EU Contribution

€ 210 000

MILTENYI BIOTEC GMBH

Germany

EU Contribution

€ 180 300

ARETA INTERNATIONAL SRL

Italy

EU Contribution

€ 120 000

ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU

Italy

EU Contribution

€ 90 400

Project information

Grant agreement ID: 223007

Status

Closed project

  • Start date

    1 November 2008

  • End date

    31 October 2011

Funded under:

FP7-HEALTH

  • Overall budget:

    € 4 052 900

  • EU contribution

    € 2 999 500

Coordinated by:

UNIVERSITA DEGLI STUDI DI FIRENZE

Italy